A New Cytotoxic 19-Nor-cardenolide from the Latex of Antiaris toxicaria

A new nor-cardenolide, named toxicarioside H (1), was isolated from the latex of Antiaris toxicaria (Pers.) Lesch (Moraceae). Its structure was elucidated on the basis of HRFAB-MS and spectroscopic techniques (IR, UV, 1D and 2D NMR). Compound 1 showed significant cytotoxicity against K562, SGC-7901,...

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Detalles Bibliográficos
Autores principales: Dai, Hao-Fu, Gan, Yu-Juan, Que, Dong-Mei, Wu, Jiao, Wen, Zhen-Chang, Mei, Wen-Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6255088/
https://www.ncbi.nlm.nih.gov/pubmed/19783952
http://dx.doi.org/10.3390/molecules14093694
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author Dai, Hao-Fu
Gan, Yu-Juan
Que, Dong-Mei
Wu, Jiao
Wen, Zhen-Chang
Mei, Wen-Li
author_facet Dai, Hao-Fu
Gan, Yu-Juan
Que, Dong-Mei
Wu, Jiao
Wen, Zhen-Chang
Mei, Wen-Li
author_sort Dai, Hao-Fu
collection PubMed
description A new nor-cardenolide, named toxicarioside H (1), was isolated from the latex of Antiaris toxicaria (Pers.) Lesch (Moraceae). Its structure was elucidated on the basis of HRFAB-MS and spectroscopic techniques (IR, UV, 1D and 2D NMR). Compound 1 showed significant cytotoxicity against K562, SGC-7901, SMMC-7721, and HeLa cell lines in vitro by MTT method.
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spelling pubmed-62550882018-11-30 A New Cytotoxic 19-Nor-cardenolide from the Latex of Antiaris toxicaria Dai, Hao-Fu Gan, Yu-Juan Que, Dong-Mei Wu, Jiao Wen, Zhen-Chang Mei, Wen-Li Molecules Article A new nor-cardenolide, named toxicarioside H (1), was isolated from the latex of Antiaris toxicaria (Pers.) Lesch (Moraceae). Its structure was elucidated on the basis of HRFAB-MS and spectroscopic techniques (IR, UV, 1D and 2D NMR). Compound 1 showed significant cytotoxicity against K562, SGC-7901, SMMC-7721, and HeLa cell lines in vitro by MTT method. Molecular Diversity Preservation International 2009-09-21 /pmc/articles/PMC6255088/ /pubmed/19783952 http://dx.doi.org/10.3390/molecules14093694 Text en © 2009 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland. This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Dai, Hao-Fu
Gan, Yu-Juan
Que, Dong-Mei
Wu, Jiao
Wen, Zhen-Chang
Mei, Wen-Li
A New Cytotoxic 19-Nor-cardenolide from the Latex of Antiaris toxicaria
title A New Cytotoxic 19-Nor-cardenolide from the Latex of Antiaris toxicaria
title_full A New Cytotoxic 19-Nor-cardenolide from the Latex of Antiaris toxicaria
title_fullStr A New Cytotoxic 19-Nor-cardenolide from the Latex of Antiaris toxicaria
title_full_unstemmed A New Cytotoxic 19-Nor-cardenolide from the Latex of Antiaris toxicaria
title_short A New Cytotoxic 19-Nor-cardenolide from the Latex of Antiaris toxicaria
title_sort new cytotoxic 19-nor-cardenolide from the latex of antiaris toxicaria
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6255088/
https://www.ncbi.nlm.nih.gov/pubmed/19783952
http://dx.doi.org/10.3390/molecules14093694
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