Cargando…

Synthesis of N-Substituted 5-Iodouracils as Antimicrobial and Anticancer Agents

This study reports the synthesis of some substituted 5-iodouracils and their bioactivities. Alkylation of 5-iodouracils gave predominately N1-substituted-(R)-5-iodouracil compounds 7a-d (R = n-C(4)H(9), s-C(4)H(9), CH(2)C(6)H(11), CH(2)C(6)H(5)) together with N1,N3-disubstituted (R) analogs 8a-b (R...

Descripción completa

Detalles Bibliográficos
Autores principales:	Prachayasittikul, Supaluk, Sornsongkhram, Nirun, Pingaew, Ratchanok, Worachartcheewan, Apilak, Ruchirawat, Somsak, Prachayasittikul, Virapong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Molecular Diversity Preservation International 2009
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6255094/ https://www.ncbi.nlm.nih.gov/pubmed/19701123 http://dx.doi.org/10.3390/molecules14082768

Ejemplares similares

A new sulfoxide analog of 1,2,3,6-tetrahydrophenylpyridine and antimicrobial activity
por: Prachayasittikul, Supaluk, et al.
Publicado: (2010)

Anticancer activity and QSAR study of sulfur-containing thiourea and sulfonamide derivatives
por: Pingaew, Ratchanok, et al.
Publicado: (2022)

Discovery of novel 1,2,3-triazole derivatives as anticancer agents using QSAR and in silico structural modification
por: Prachayasittikul, Veda, et al.
Publicado: (2015)

Synthesis of acetamidosulfonamide derivatives with antioxidative and QSAR studies
por: Worachartcheewan, Apilak, et al.
Publicado: (2022)

Investigation on biological activities of anthranilic acid sulfonamide analogs
por: Doungsoongnuen, Sutanun, et al.
Publicado: (2011)

Aromatase inhibitory activity of 1,4-naphthoquinone derivatives and QSAR study
por: Prachayasittikul, Veda, et al.
Publicado: (2017)

Investigations on Anticancer and Antimalarial Activities of Indole-Sulfonamide Derivatives and In Silico Studies
por: Pingaew, Ratchanok, et al.
Publicado: (2021)

Investigation of aromatase inhibitory activity of metal complexes of 8-hydroxyquinoline and uracil derivatives
por: Prachayasittikul, Veda, et al.
Publicado: (2014)

Synthesis, Cytotoxic and Antimalarial Activities of Benzoyl Thiosemicarbazone Analogs of Isoquinoline and Related Compounds
por: Pingaew, Ratchanok, et al.
Publicado: (2010)

Antimicrobial and Antioxidative Activities of Bioactive Constituents from Hydnophytum formicarum Jack
por: Prachayasittikul, Supaluk, et al.
Publicado: (2008)

Bioactive Metabolites from Spilanthes acmella Murr.
por: Prachayasittikul, Supaluk, et al.
Publicado: (2009)

Elucidating the Structure-Activity Relationships of the Vasorelaxation and Antioxidation Properties of Thionicotinic Acid Derivatives
por: Prachayasittikul, Supaluk, et al.
Publicado: (2010)

Bioactive 4-hydroxycinnamide and bioactivities of Polyalthia cerasoides
por: Treeratanapiboon, Lertyot, et al.
Publicado: (2011)

In silico and multi-spectroscopic analyses on the interaction of 5-amino-8-hydroxyquinoline and bovine serum albumin as a potential anticancer agent
por: Ruankham, Waralee, et al.
Publicado: (2021)

Discovery of Anilino-1,4-naphthoquinones as Potent EGFR Tyrosine Kinase Inhibitors: Synthesis, Biological Evaluation, and Comprehensive Molecular Modeling
por: Mahalapbutr, Panupong, et al.
Publicado: (2022)

Discovery of Novel Naphthoquinone–Chalcone Hybrids as Potent FGFR1 Tyrosine Kinase Inhibitors: Synthesis, Biological Evaluation, and Molecular Modeling
por: Leechaisit, Ronnakorn, et al.
Publicado: (2023)

Aminochalcones Attenuate Neuronal Cell Death under Oxidative Damage via Sirtuin 1 Activity
por: Apiraksattayakul, Setthawut, et al.
Publicado: (2023)

Probing the origins of aromatase inhibitory activity of disubstituted coumarins via QSAR and molecular docking
por: Worachartcheewan, Apilak, et al.
Publicado: (2014)

Rational design of novel coumarins: A potential trend for antioxidants in cosmetics
por: Worachartcheewan, Apilak, et al.
Publicado: (2020)

8-Hydroxyquinolines: a review of their metal chelating properties and medicinal applications
por: Prachayasittikul, Veda, et al.
Publicado: (2013)

High therapeutic potential of Spilanthes acmella: A review
por: Prachayasittikul, Veda, et al.
Publicado: (2013)

Derivatives (halogen, nitro and amino) of 8-hydroxyquinoline with highly potent antimicrobial and antioxidant activities
por: Cherdtrakulkiat, Rungrot, et al.
Publicado: (2016)

Antimalarial and antimicrobial activities of 8-Aminoquinoline-Uracils metal complexes
por: Phopin, Kamonrat, et al.
Publicado: (2016)

New bioactive triterpenoids and antimalarial activity of Diospyros rubra Lec.
por: Prachayasittikul, Supaluk, et al.
Publicado: (2010)

Classification of P-glycoprotein-interacting compounds using machine learning methods
por: Prachayasittikul, Veda, et al.
Publicado: (2015)

Neuroprotective Properties of Bis-Sulfonamide Derivatives Against 6-OHDA-Induced Parkinson's Model via Sirtuin 1 Activity and in silico Pharmacokinetic Properties
por: Apiraksattayakul, Setthawut, et al.
Publicado: (2022)

Vasorelaxant and Antioxidant Activities of Spilanthes acmella Murr.
por: Wongsawatkul, Orapin, et al.
Publicado: (2008)

Bioactive Azafluorenone Alkaloids from Polyalthia debilis (Pierre) Finet & Gagnep
por: Prachayasittikul, Supaluk, et al.
Publicado: (2009)

Data mining for the identification of metabolic syndrome status
por: Worachartcheewan, Apilak, et al.
Publicado: (2018)

Quantitative population-health relationship (QPHR) for assessing metabolic syndrome
por: Worachartcheewan, Apilak, et al.
Publicado: (2013)

Nitroxoline: a potent antimicrobial agent against multidrug resistant Enterobacteriaceae
por: Cherdtrakulkiat, Rungrot, et al.
Publicado: (2019)

Predicting Metabolic Syndrome Using the Random Forest Method
por: Worachartcheewan, Apilak, et al.
Publicado: (2015)

Effect of 8-hydroxyquinoline and derivatives on human neuroblastoma SH-SY5Y cells under high glucose
por: Suwanjang, Wilasinee, et al.
Publicado: (2016)

Quinoline-based clioquinol and nitroxoline exhibit anticancer activity inducing FoxM1 inhibition in cholangiocarcinoma cells
por: Chan-on, Waraporn, et al.
Publicado: (2015)

Effect of cranberry dietary supplements with different brands on human CYP3A4 enzyme
por: Wanwimolruk, Sompon, et al.
Publicado: (2012)

QSAR-driven rational design of novel DNA methyltransferase 1 inhibitors
por: Phanus-umporn, Chuleeporn, et al.
Publicado: (2020)

A Unified Proteochemometric Model for Prediction of Inhibition of Cytochrome P450 Isoforms
por: Lapins, Maris, et al.
Publicado: (2013)

Machine learning approaches for discerning intercorrelation of hematological parameters and glucose level for identification of diabetes mellitus
por: Worachartcheewan, Apilak, et al.
Publicado: (2013)

Insight into the Molecular Interaction of Cloxyquin (5-chloro-8-hydroxyquinoline) with Bovine Serum Albumin: Biophysical Analysis and Computational Simulation
por: Phopin, Kamonrat, et al.
Publicado: (2019)

Modulatory Effects of Alpha-Mangostin Mediated by SIRT1/3-FOXO3a Pathway in Oxidative Stress-Induced Neuronal Cells
por: Ruankham, Waralee, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_tn7d8sog1ht6ef4eh67sm973m6