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Amides from Piper capense with CNS Activity – A Preliminary SAR Analysis
Piper capense L.f. (Piperaceae) is used traditionally in South Africa as a sleep inducing remedy. Bioassay-guided fractionation of the roots of P. capense led to the isolation of piperine (1) and 4,5-dihydropiperine (2), which showed moderate affinity for the benzodiazepine site on the GABA(A) recep...
Autores principales: | Pedersen, Mikael E., Metzler, Bjørn, Stafford, Gary I., van Staden, Johannes, Jäger, Anna K., Rasmussen, Hasse B. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Molecular Diversity Preservation International
2009
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6255099/ https://www.ncbi.nlm.nih.gov/pubmed/19783959 http://dx.doi.org/10.3390/molecules14093833 |
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