450. Using Geographical Information Systems to Interpret the Efficacy of Mass Drug Administration for Soil-Transmitted Helminthiasis in Rural Madagascar

BACKGROUND: In Madagascar, mass drug administration (MDA) of anti-parasitics is administered every 6 months to combat soil-transmitted helminthiasis (STH) in school-aged children, although little information exists as to its efficacy. In recent years, geographical information systems (GIS) have been used for visualization of patterns in disease epidemiology. This inexpensive technology may be leveraged to aid in education of local health workers toward a more integrated approach to control STH. METHODS: Baseline questionnaires and stool/blood samples were collected from participants of Mangevo, a rural village in southeast Madagascar. GPS coordinates and qualitative descriptions were collected from all village homes, common latrines, and animal pens. All children 5–15 years old were given MDA per WHO protocol. Stool was again collected from these children 2 weeks later and 3 months later. Parasitological examination of stool samples for STH eggs was performed using Spontaneous Sedimentation Technique. Results were overlaid onto GIS maps and used to further educate the local mobile health team. RESULTS: A total of 183 participants were eligible for the study. Analysis found 89% of adults >15 years old were infected with one or more parasite and 100% of children 5–15 were infected with one or more parasite at time 0. Trichuris trichuria prevalence fell 8% (P < 0.5) in 2 weeks and climbed 17% (P < 0.05) by 3 months follow-up. Ascaris lumbricoides prevalence fell 96% (P < 0.0001) in the 2 weeks and climbed 95% (P < 0.0001) by 3 months follow-up. Hookworm prevalence dropped 89% (P < 0.0001) in 2 weeks and climbed 5% (P < 0.5) by 3 months follow-up. Prevalence data, descriptive results, and GPS coordinates of village homes were integrated into a GIS maps pre- and post-MDA of children, and pre-MDA for adults. [Image: see text] [Image: see text] CONCLUSION: While GIS has been used to yield insights into the ecology of infection, this study examined the efficacy of the current MDA through the lens of small scale GIS mapping. This may be an ideal and inexpensive technology to help in the implementation of future interventions of the government-mandated STH treatment protocol and work toward the strengthening of local health teams. DISCLOSURES: All authors: No reported disclosures.