Silencing of retrotransposon-derived imprinted gene RTL1 is the main cause for postimplantational failures in mammalian cloning

Substantial rates of fetal loss plague all in vitro procedures involving embryo manipulations, including human-assisted reproduction, and are especially problematic for mammalian cloning where over 90% of reconstructed nuclear transfer embryos are typically lost during pregnancy. However, the epigen...

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Detalles Bibliográficos
Autores principales: Yu, Dawei, Wang, Jing, Zou, Huiying, Feng, Tao, Chen, Lei, Li, Jia, Qi, Xiaolan, Li, Zhifang, Duan, Xiaoyue, Xu, Chunlong, Zhang, Liang, Long, Xi, Lan, Jing, Chen, Chao, Wang, Chao, Xu, Xinyu, Ren, Jilong, Zhao, Yiqiang, Hu, Xiaoxiang, Lian, Zhengxing, Men, Hongsheng, Pan, Dengke, Li, Ning, Capecchi, Mario R., Du, Xuguang, Zhao, Yaofeng, Wu, Sen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2018
Materias:
PNAS Plus
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6255163/
https://www.ncbi.nlm.nih.gov/pubmed/30381455
http://dx.doi.org/10.1073/pnas.1814514115

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