Structure-guided development of selective M3 muscarinic acetylcholine receptor antagonists

Drugs that treat chronic obstructive pulmonary disease by antagonizing the M3 muscarinic acetylcholine receptor (M3R) have had a significant effect on health, but can suffer from their lack of selectivity against the M2R subtype, which modulates heart rate. Beginning with the crystal structures of M...

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Detalles Bibliográficos
Autores principales: Liu, Hongtao, Hofmann, Josefa, Fish, Inbar, Schaake, Benjamin, Eitel, Katrin, Bartuschat, Amelie, Kaindl, Jonas, Rampp, Hannelore, Banerjee, Ashutosh, Hübner, Harald, Clark, Mary J., Vincent, Sandra G., Fisher, John T., Heinrich, Markus R., Hirata, Kunio, Liu, Xiangyu, Sunahara, Roger K., Shoichet, Brian K., Kobilka, Brian K., Gmeiner, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2018
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6255194/
https://www.ncbi.nlm.nih.gov/pubmed/30404914
http://dx.doi.org/10.1073/pnas.1813988115

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