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Optimal molecular crowding accelerates group II intron folding and maximizes catalysis
Unlike in vivo conditions, group II intron ribozymes are known to require high magnesium(II) concentrations ([Mg(2+)]) and high temperatures (42 °C) for folding and catalysis in vitro. A possible explanation for this difference is the highly crowded cellular environment, which can be mimicked in vit...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
National Academy of Sciences
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6255197/ https://www.ncbi.nlm.nih.gov/pubmed/30397128 http://dx.doi.org/10.1073/pnas.1806685115 |