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2390. Avibactam Sensitizes NDM Klebsiella pneumoniae to Innate Immune Killing by Human Cathelicidin LL-37, Serum, Neutrophils, and Platelets

BACKGROUND: Avibactam (AVI) is a broad-spectrum intravenous non-β-lactam/β-lactamase inhibitor with no reported activity against metallo-β-lactamases such as New Delhi metallo-β-lactamases (NDM). Structural similarities between β-lactamases and bacterial penicillin-binding proteins (PBPs) have led i...

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Detalles Bibliográficos
Autores principales:	Ulloa, Erlinda Rose, Dillon, Nicholas, Sakoulas, George, Nizet, Victor
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2018
Materias:	Abstracts
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6255312/ http://dx.doi.org/10.1093/ofid/ofy210.2043

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