Synthesis and Olfactory Evaluation of Bulky Moiety-Modified Analogues to the Sandalwood Odorant Polysantol(®)

Five new bulky moiety-modified analogues of the sandalwood odorant Polysantol(®) have been synthesized by aldol condensation of appropriate aldehydes with butanone, deconjugative α-methylation of the resulting α,β-unsaturated ketones, and reduction of the corresponding β,γ-unsaturated ketones. The f...

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Detalles Bibliográficos
Autores principales: Chapado, Laura, Linares-Palomino, Pablo J., Nogueras, Manuel, Sánchez, Adolfo, Altarejos, Joaquín
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6255316/
https://www.ncbi.nlm.nih.gov/pubmed/19701124
http://dx.doi.org/10.3390/molecules14082780
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author Chapado, Laura
Linares-Palomino, Pablo J.
Nogueras, Manuel
Sánchez, Adolfo
Altarejos, Joaquín
author_facet Chapado, Laura
Linares-Palomino, Pablo J.
Nogueras, Manuel
Sánchez, Adolfo
Altarejos, Joaquín
author_sort Chapado, Laura
collection PubMed
description Five new bulky moiety-modified analogues of the sandalwood odorant Polysantol(®) have been synthesized by aldol condensation of appropriate aldehydes with butanone, deconjugative α-methylation of the resulting α,β-unsaturated ketones, and reduction of the corresponding β,γ-unsaturated ketones. The final compounds were evaluated organoleptically and one of them seemed to be of special interest for its natural sandalwood scent.
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spelling pubmed-62553162018-11-30 Synthesis and Olfactory Evaluation of Bulky Moiety-Modified Analogues to the Sandalwood Odorant Polysantol(®) Chapado, Laura Linares-Palomino, Pablo J. Nogueras, Manuel Sánchez, Adolfo Altarejos, Joaquín Molecules Article Five new bulky moiety-modified analogues of the sandalwood odorant Polysantol(®) have been synthesized by aldol condensation of appropriate aldehydes with butanone, deconjugative α-methylation of the resulting α,β-unsaturated ketones, and reduction of the corresponding β,γ-unsaturated ketones. The final compounds were evaluated organoleptically and one of them seemed to be of special interest for its natural sandalwood scent. Molecular Diversity Preservation International 2009-07-28 /pmc/articles/PMC6255316/ /pubmed/19701124 http://dx.doi.org/10.3390/molecules14082780 Text en © 2009 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland. This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Chapado, Laura
Linares-Palomino, Pablo J.
Nogueras, Manuel
Sánchez, Adolfo
Altarejos, Joaquín
Synthesis and Olfactory Evaluation of Bulky Moiety-Modified Analogues to the Sandalwood Odorant Polysantol(®)
title Synthesis and Olfactory Evaluation of Bulky Moiety-Modified Analogues to the Sandalwood Odorant Polysantol(®)
title_full Synthesis and Olfactory Evaluation of Bulky Moiety-Modified Analogues to the Sandalwood Odorant Polysantol(®)
title_fullStr Synthesis and Olfactory Evaluation of Bulky Moiety-Modified Analogues to the Sandalwood Odorant Polysantol(®)
title_full_unstemmed Synthesis and Olfactory Evaluation of Bulky Moiety-Modified Analogues to the Sandalwood Odorant Polysantol(®)
title_short Synthesis and Olfactory Evaluation of Bulky Moiety-Modified Analogues to the Sandalwood Odorant Polysantol(®)
title_sort synthesis and olfactory evaluation of bulky moiety-modified analogues to the sandalwood odorant polysantol(®)
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6255316/
https://www.ncbi.nlm.nih.gov/pubmed/19701124
http://dx.doi.org/10.3390/molecules14082780
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