Carnitine Conjugate of Nipecotic Acid: A New Example of Dual Prodrug

As a novel example of improved entry of poorly delivered drugs into the brain by means of nutrient conjugates, L-carnitine was conjugated to nipecotic acid and the capacity to antagonize PTZ-induced convulsions of this novel entity was evaluated.

Detalles Bibliográficos
Autores principales: Napolitano, Carmela, Scaglianti, Martina, Scalambra, Emanuela, Manfredini, Stefano, Ferraro, Luca, Beggiato, Sarah, Vertuani, Silvia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International 2009
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6255320/
https://www.ncbi.nlm.nih.gov/pubmed/19783924
http://dx.doi.org/10.3390/molecules14093268
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author Napolitano, Carmela
Scaglianti, Martina
Scalambra, Emanuela
Manfredini, Stefano
Ferraro, Luca
Beggiato, Sarah
Vertuani, Silvia
author_facet Napolitano, Carmela
Scaglianti, Martina
Scalambra, Emanuela
Manfredini, Stefano
Ferraro, Luca
Beggiato, Sarah
Vertuani, Silvia
author_sort Napolitano, Carmela
collection PubMed
description As a novel example of improved entry of poorly delivered drugs into the brain by means of nutrient conjugates, L-carnitine was conjugated to nipecotic acid and the capacity to antagonize PTZ-induced convulsions of this novel entity was evaluated.
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spelling pubmed-62553202018-11-30 Carnitine Conjugate of Nipecotic Acid: A New Example of Dual Prodrug Napolitano, Carmela Scaglianti, Martina Scalambra, Emanuela Manfredini, Stefano Ferraro, Luca Beggiato, Sarah Vertuani, Silvia Molecules Communication As a novel example of improved entry of poorly delivered drugs into the brain by means of nutrient conjugates, L-carnitine was conjugated to nipecotic acid and the capacity to antagonize PTZ-induced convulsions of this novel entity was evaluated. Molecular Diversity Preservation International 2009-08-31 /pmc/articles/PMC6255320/ /pubmed/19783924 http://dx.doi.org/10.3390/molecules14093268 Text en © 2009 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Communication
Napolitano, Carmela
Scaglianti, Martina
Scalambra, Emanuela
Manfredini, Stefano
Ferraro, Luca
Beggiato, Sarah
Vertuani, Silvia
Carnitine Conjugate of Nipecotic Acid: A New Example of Dual Prodrug
title Carnitine Conjugate of Nipecotic Acid: A New Example of Dual Prodrug
title_full Carnitine Conjugate of Nipecotic Acid: A New Example of Dual Prodrug
title_fullStr Carnitine Conjugate of Nipecotic Acid: A New Example of Dual Prodrug
title_full_unstemmed Carnitine Conjugate of Nipecotic Acid: A New Example of Dual Prodrug
title_short Carnitine Conjugate of Nipecotic Acid: A New Example of Dual Prodrug
title_sort carnitine conjugate of nipecotic acid: a new example of dual prodrug
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6255320/
https://www.ncbi.nlm.nih.gov/pubmed/19783924
http://dx.doi.org/10.3390/molecules14093268
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