The Effect of Long-Running Severe Selenium-Deficiency on the Amount of Iron and Zinc in the Organs of Rats

The amounts of selenium (Se), iron (Fe), and zinc (Zn) in the liver, kidney, and spleen as a function of age of rats measured using instrumental neutron activation analysis were compared between Se-deficient (SeD) rats and normal rats. The SeD model rats can live for more than 50 weeks. The effect o...

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Autores principales: Matsumoto, Ken-ichiro, Terada, Sachiyo, Ariyoshi, Marie, Okajo, Aya, Hisamatsu, Atsushi, Ui, Iori, Endo, Kazutoyo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6255328/
https://www.ncbi.nlm.nih.gov/pubmed/19924078
http://dx.doi.org/10.3390/molecules14114440
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author Matsumoto, Ken-ichiro
Terada, Sachiyo
Ariyoshi, Marie
Okajo, Aya
Hisamatsu, Atsushi
Ui, Iori
Endo, Kazutoyo
author_facet Matsumoto, Ken-ichiro
Terada, Sachiyo
Ariyoshi, Marie
Okajo, Aya
Hisamatsu, Atsushi
Ui, Iori
Endo, Kazutoyo
author_sort Matsumoto, Ken-ichiro
collection PubMed
description The amounts of selenium (Se), iron (Fe), and zinc (Zn) in the liver, kidney, and spleen as a function of age of rats measured using instrumental neutron activation analysis were compared between Se-deficient (SeD) rats and normal rats. The SeD model rats can live for more than 50 weeks. The effect of Se-deficinecy in rats might be weak, compared to the marked malfunction of GSH-Px. The SeD rats can be considered as a model of non-lethal chronic oxidative stress. Fluctuations of Fe and Zn in the liver of Se-deficient rats were observed. The amount of redox-relating minerals, such as Fe and Zn, in SeD rat organs is changeable depending on the age.
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spelling pubmed-62553282018-11-30 The Effect of Long-Running Severe Selenium-Deficiency on the Amount of Iron and Zinc in the Organs of Rats Matsumoto, Ken-ichiro Terada, Sachiyo Ariyoshi, Marie Okajo, Aya Hisamatsu, Atsushi Ui, Iori Endo, Kazutoyo Molecules Article The amounts of selenium (Se), iron (Fe), and zinc (Zn) in the liver, kidney, and spleen as a function of age of rats measured using instrumental neutron activation analysis were compared between Se-deficient (SeD) rats and normal rats. The SeD model rats can live for more than 50 weeks. The effect of Se-deficinecy in rats might be weak, compared to the marked malfunction of GSH-Px. The SeD rats can be considered as a model of non-lethal chronic oxidative stress. Fluctuations of Fe and Zn in the liver of Se-deficient rats were observed. The amount of redox-relating minerals, such as Fe and Zn, in SeD rat organs is changeable depending on the age. Molecular Diversity Preservation International 2009-11-05 /pmc/articles/PMC6255328/ /pubmed/19924078 http://dx.doi.org/10.3390/molecules14114440 Text en © 2009 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Matsumoto, Ken-ichiro
Terada, Sachiyo
Ariyoshi, Marie
Okajo, Aya
Hisamatsu, Atsushi
Ui, Iori
Endo, Kazutoyo
The Effect of Long-Running Severe Selenium-Deficiency on the Amount of Iron and Zinc in the Organs of Rats
title The Effect of Long-Running Severe Selenium-Deficiency on the Amount of Iron and Zinc in the Organs of Rats
title_full The Effect of Long-Running Severe Selenium-Deficiency on the Amount of Iron and Zinc in the Organs of Rats
title_fullStr The Effect of Long-Running Severe Selenium-Deficiency on the Amount of Iron and Zinc in the Organs of Rats
title_full_unstemmed The Effect of Long-Running Severe Selenium-Deficiency on the Amount of Iron and Zinc in the Organs of Rats
title_short The Effect of Long-Running Severe Selenium-Deficiency on the Amount of Iron and Zinc in the Organs of Rats
title_sort effect of long-running severe selenium-deficiency on the amount of iron and zinc in the organs of rats
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6255328/
https://www.ncbi.nlm.nih.gov/pubmed/19924078
http://dx.doi.org/10.3390/molecules14114440
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