New Conjugated Benzothiazole-N-oxides: Synthesis and Biological Activity

Eleven new 2-styrylbenzothiazole-N-oxides have been prepared by aldol – type condensation reactions between 2-methylbenzothiazole–N-oxide and para-substituted benzaldehydes. Compounds with cyclic amino substituents showed typical push-pull molecule properties. Four compounds were tested against vari...

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Detalles Bibliográficos
Autores principales: Gajdoš, Peter, Magdolen, Peter, Zahradník, Pavol, Foltínová, Pavlína
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6255338/
https://www.ncbi.nlm.nih.gov/pubmed/20032900
http://dx.doi.org/10.3390/molecules14125382
Descripción
Sumario:Eleven new 2-styrylbenzothiazole-N-oxides have been prepared by aldol – type condensation reactions between 2-methylbenzothiazole–N-oxide and para-substituted benzaldehydes. Compounds with cyclic amino substituents showed typical push-pull molecule properties. Four compounds were tested against various bacterial strains as well as the protozoan Euglena gracilis as model microorganisms. Unlike previously prepared analogous benzothiazolium salts, only weak activity was recorded.

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