New Conjugated Benzothiazole-N-oxides: Synthesis and Biological Activity

Eleven new 2-styrylbenzothiazole-N-oxides have been prepared by aldol – type condensation reactions between 2-methylbenzothiazole–N-oxide and para-substituted benzaldehydes. Compounds with cyclic amino substituents showed typical push-pull molecule properties. Four compounds were tested against vari...

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Autores principales: Gajdoš, Peter, Magdolen, Peter, Zahradník, Pavol, Foltínová, Pavlína
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6255338/
https://www.ncbi.nlm.nih.gov/pubmed/20032900
http://dx.doi.org/10.3390/molecules14125382
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author Gajdoš, Peter
Magdolen, Peter
Zahradník, Pavol
Foltínová, Pavlína
author_facet Gajdoš, Peter
Magdolen, Peter
Zahradník, Pavol
Foltínová, Pavlína
author_sort Gajdoš, Peter
collection PubMed
description Eleven new 2-styrylbenzothiazole-N-oxides have been prepared by aldol – type condensation reactions between 2-methylbenzothiazole–N-oxide and para-substituted benzaldehydes. Compounds with cyclic amino substituents showed typical push-pull molecule properties. Four compounds were tested against various bacterial strains as well as the protozoan Euglena gracilis as model microorganisms. Unlike previously prepared analogous benzothiazolium salts, only weak activity was recorded.
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spelling pubmed-62553382018-11-30 New Conjugated Benzothiazole-N-oxides: Synthesis and Biological Activity Gajdoš, Peter Magdolen, Peter Zahradník, Pavol Foltínová, Pavlína Molecules Article Eleven new 2-styrylbenzothiazole-N-oxides have been prepared by aldol – type condensation reactions between 2-methylbenzothiazole–N-oxide and para-substituted benzaldehydes. Compounds with cyclic amino substituents showed typical push-pull molecule properties. Four compounds were tested against various bacterial strains as well as the protozoan Euglena gracilis as model microorganisms. Unlike previously prepared analogous benzothiazolium salts, only weak activity was recorded. Molecular Diversity Preservation International 2009-12-23 /pmc/articles/PMC6255338/ /pubmed/20032900 http://dx.doi.org/10.3390/molecules14125382 Text en © 2009 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland. This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Gajdoš, Peter
Magdolen, Peter
Zahradník, Pavol
Foltínová, Pavlína
New Conjugated Benzothiazole-N-oxides: Synthesis and Biological Activity
title New Conjugated Benzothiazole-N-oxides: Synthesis and Biological Activity
title_full New Conjugated Benzothiazole-N-oxides: Synthesis and Biological Activity
title_fullStr New Conjugated Benzothiazole-N-oxides: Synthesis and Biological Activity
title_full_unstemmed New Conjugated Benzothiazole-N-oxides: Synthesis and Biological Activity
title_short New Conjugated Benzothiazole-N-oxides: Synthesis and Biological Activity
title_sort new conjugated benzothiazole-n-oxides: synthesis and biological activity
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6255338/
https://www.ncbi.nlm.nih.gov/pubmed/20032900
http://dx.doi.org/10.3390/molecules14125382
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