Preparation and Characterization of Novel Gellan Gum Hydrogels Suitable for Modified Drug Release

Innovative hydrogels obtained by physical and chemical crosslinking of deacylated Gellan gum have been characterized in terms of water uptake, rheological properties and compressibility, and the behaviour of the tested materials, according to the type of the obtained network, is thoroughly discussed...

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Autores principales: Matricardi, Pietro, Cencetti, Claudia, Ria, Roberto, Alhaique, Franco, Coviello, Tommasina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6255374/
https://www.ncbi.nlm.nih.gov/pubmed/19783932
http://dx.doi.org/10.3390/molecules14093376
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author Matricardi, Pietro
Cencetti, Claudia
Ria, Roberto
Alhaique, Franco
Coviello, Tommasina
author_facet Matricardi, Pietro
Cencetti, Claudia
Ria, Roberto
Alhaique, Franco
Coviello, Tommasina
author_sort Matricardi, Pietro
collection PubMed
description Innovative hydrogels obtained by physical and chemical crosslinking of deacylated Gellan gum have been characterized in terms of water uptake, rheological properties and compressibility, and the behaviour of the tested materials, according to the type of the obtained network, is thoroughly discussed. The release from the various gels of loaded model molecules of different steric hindrance was also investigated and the trend of the release profiles has been related to the structures proposed for the physical and the chemical hydrogel.
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spelling pubmed-62553742018-11-30 Preparation and Characterization of Novel Gellan Gum Hydrogels Suitable for Modified Drug Release Matricardi, Pietro Cencetti, Claudia Ria, Roberto Alhaique, Franco Coviello, Tommasina Molecules Article Innovative hydrogels obtained by physical and chemical crosslinking of deacylated Gellan gum have been characterized in terms of water uptake, rheological properties and compressibility, and the behaviour of the tested materials, according to the type of the obtained network, is thoroughly discussed. The release from the various gels of loaded model molecules of different steric hindrance was also investigated and the trend of the release profiles has been related to the structures proposed for the physical and the chemical hydrogel. Molecular Diversity Preservation International 2009-09-03 /pmc/articles/PMC6255374/ /pubmed/19783932 http://dx.doi.org/10.3390/molecules14093376 Text en © 2009 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland. This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Matricardi, Pietro
Cencetti, Claudia
Ria, Roberto
Alhaique, Franco
Coviello, Tommasina
Preparation and Characterization of Novel Gellan Gum Hydrogels Suitable for Modified Drug Release
title Preparation and Characterization of Novel Gellan Gum Hydrogels Suitable for Modified Drug Release
title_full Preparation and Characterization of Novel Gellan Gum Hydrogels Suitable for Modified Drug Release
title_fullStr Preparation and Characterization of Novel Gellan Gum Hydrogels Suitable for Modified Drug Release
title_full_unstemmed Preparation and Characterization of Novel Gellan Gum Hydrogels Suitable for Modified Drug Release
title_short Preparation and Characterization of Novel Gellan Gum Hydrogels Suitable for Modified Drug Release
title_sort preparation and characterization of novel gellan gum hydrogels suitable for modified drug release
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6255374/
https://www.ncbi.nlm.nih.gov/pubmed/19783932
http://dx.doi.org/10.3390/molecules14093376
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