Synthesis and Antitumor Activities of Phenanthrene-Based Alkaloids

A series of phenanthrene-based tylophorine derivatives (PBTs) were synthesized and their cytotoxic activities against the H460 human large-cell lung carcinoma cell line were evaluated. Among these compounds, N-(3-hydroxy-2,6,7-tri-methoxyphenanthr-9-ylmethyl)-l-prolinol (5a), and N-(3-hydroxy-2,6,7-...

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Detalles Bibliográficos
Autores principales: Li, Songtao, Han, Li, Sun, Liang, Zheng, Dan, Liu, Jiang, Fu, Yingbo, Huang, Xueshi, Wang, Zhanyou
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6255436/
https://www.ncbi.nlm.nih.gov/pubmed/20032876
http://dx.doi.org/10.3390/molecules14125042
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author Li, Songtao
Han, Li
Sun, Liang
Zheng, Dan
Liu, Jiang
Fu, Yingbo
Huang, Xueshi
Wang, Zhanyou
author_facet Li, Songtao
Han, Li
Sun, Liang
Zheng, Dan
Liu, Jiang
Fu, Yingbo
Huang, Xueshi
Wang, Zhanyou
author_sort Li, Songtao
collection PubMed
description A series of phenanthrene-based tylophorine derivatives (PBTs) were synthesized and their cytotoxic activities against the H460 human large-cell lung carcinoma cell line were evaluated. Among these compounds, N-(3-hydroxy-2,6,7-tri-methoxyphenanthr-9-ylmethyl)-l-prolinol (5a), and N-(3-hydroxy-2,6,7-trimethoxy-phenanthr-9-ylmethyl)-l-valinol (9) exhibited good activities, with IC(50) values of 11.6 and 6.1 μM, respectively.
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spelling pubmed-62554362018-11-30 Synthesis and Antitumor Activities of Phenanthrene-Based Alkaloids Li, Songtao Han, Li Sun, Liang Zheng, Dan Liu, Jiang Fu, Yingbo Huang, Xueshi Wang, Zhanyou Molecules Article A series of phenanthrene-based tylophorine derivatives (PBTs) were synthesized and their cytotoxic activities against the H460 human large-cell lung carcinoma cell line were evaluated. Among these compounds, N-(3-hydroxy-2,6,7-tri-methoxyphenanthr-9-ylmethyl)-l-prolinol (5a), and N-(3-hydroxy-2,6,7-trimethoxy-phenanthr-9-ylmethyl)-l-valinol (9) exhibited good activities, with IC(50) values of 11.6 and 6.1 μM, respectively. Molecular Diversity Preservation International 2009-12-07 /pmc/articles/PMC6255436/ /pubmed/20032876 http://dx.doi.org/10.3390/molecules14125042 Text en © 2009 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland. This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Li, Songtao
Han, Li
Sun, Liang
Zheng, Dan
Liu, Jiang
Fu, Yingbo
Huang, Xueshi
Wang, Zhanyou
Synthesis and Antitumor Activities of Phenanthrene-Based Alkaloids
title Synthesis and Antitumor Activities of Phenanthrene-Based Alkaloids
title_full Synthesis and Antitumor Activities of Phenanthrene-Based Alkaloids
title_fullStr Synthesis and Antitumor Activities of Phenanthrene-Based Alkaloids
title_full_unstemmed Synthesis and Antitumor Activities of Phenanthrene-Based Alkaloids
title_short Synthesis and Antitumor Activities of Phenanthrene-Based Alkaloids
title_sort synthesis and antitumor activities of phenanthrene-based alkaloids
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6255436/
https://www.ncbi.nlm.nih.gov/pubmed/20032876
http://dx.doi.org/10.3390/molecules14125042
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