751. Acute Respiratory Illness Hospitalizations Among Young Children: Multi-Center Viral Surveillance Network, United States, 2015–2016

BACKGROUND: Viral infections are a significant cause of severe acute respiratory illnesses (ARI) in young children. Understanding the current epidemiology of these viruses is important for informing treatment and prevention measures. We describe the New Vaccine Surveillance Network (NVSN) and report...

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Autores principales: Rha, Brian, Campbell, Angela P, McDaniel, Darius, Selvarangan, Rangaraj, Halasa, Natasha, Englund, Janet, Boom, Julie A, Azimi, Parvin H, Weinberg, Geoffrey A, Staat, Mary A, Singer, Monica N, Sahni, Leila C, McNeal, Monica, Klein, Eileen J, Harrison, Christopher J, Williams, John V, Yu, Joana, Figueroa-Downing, Daniella, Prill, Mila M, Whitaker, Brett L, Curns, Aaron T, Langley, Gayle E, Payne, Daniel C, Gerber, Susan I
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6255643/
http://dx.doi.org/10.1093/ofid/ofy210.758
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author Rha, Brian
Campbell, Angela P
McDaniel, Darius
Selvarangan, Rangaraj
Halasa, Natasha
Englund, Janet
Boom, Julie A
Azimi, Parvin H
Weinberg, Geoffrey A
Staat, Mary A
Singer, Monica N
Sahni, Leila C
McNeal, Monica
Klein, Eileen J
Harrison, Christopher J
Williams, John V
Yu, Joana
Figueroa-Downing, Daniella
Prill, Mila M
Whitaker, Brett L
Curns, Aaron T
Langley, Gayle E
Payne, Daniel C
Gerber, Susan I
author_facet Rha, Brian
Campbell, Angela P
McDaniel, Darius
Selvarangan, Rangaraj
Halasa, Natasha
Englund, Janet
Boom, Julie A
Azimi, Parvin H
Weinberg, Geoffrey A
Staat, Mary A
Singer, Monica N
Sahni, Leila C
McNeal, Monica
Klein, Eileen J
Harrison, Christopher J
Williams, John V
Yu, Joana
Figueroa-Downing, Daniella
Prill, Mila M
Whitaker, Brett L
Curns, Aaron T
Langley, Gayle E
Payne, Daniel C
Gerber, Susan I
author_sort Rha, Brian
collection PubMed
description BACKGROUND: Viral infections are a significant cause of severe acute respiratory illnesses (ARI) in young children. Understanding the current epidemiology of these viruses is important for informing treatment and prevention measures. We describe the New Vaccine Surveillance Network (NVSN) and report preliminary results from 2015 to 2016. METHODS: Prospective active surveillance for hospitalized ARI was conducted from November 1, 2015 to June 30, 2016 among children <5 years of age at seven pediatric hospital sites (figure) using a broad case definition based on admission diagnoses. Parent interviews and medical chart reviews were performed, and mid-turbinate nasal and throat flocked swabs and/or tracheal aspirates were tested for adenovirus, human metapneumovirus (HMPV), influenza, parainfluenza viruses (PIV) 1–3, respiratory syncytial virus (RSV), and rhinovirus/enterovirus using molecular diagnostic assays at each site. Asymptomatic controls <5 years of age were also enrolled. RESULTS: Among 2,974 hospitalized children with ARI whose specimens were tested for viruses, 2,228 (75%) were <2 years old, with 745 (25%) 0–2 months, and 309 (10%) 3–5 months old. The majority were male (58%; n = 1,732) and 63% (n = 1,093) had no documented comorbid conditions. The median length of stay was 2 days; 1,683 (57%) received supplemental oxygen, 435 (15%) were admitted to intensive care, 95 (3%) required mechanical ventilation, and 1 (<1%) died. Viruses were detected in 2,242 (75%) children with ARI, with >1 virus detected in 234 (8%). RSV was detected in 1,039 (35%) children with ARI, HMPV in 245 (8%), influenza in 104 (4%), and PIV-1, PIV-2, and PIV-3 in 49 (2%), 2 (<1%), and 78 (3%), respectively. Rhinovirus/enterovirus was detected in 849 (29%) and adenovirus in 118 (4%) children with ARI, but were also detected in 18% (n = 227) and 5% (n = 60), respectively, of the 1,243 controls tested; the other viruses were more rarely detected in controls. CONCLUSION: During the 2015–2016 season, viral detections were common in young children hospitalized for ARI at seven US sites. NVSN combines clinical data with current molecular laboratory techniques to describe respiratory virus epidemiology in cases of hospitalized pediatric ARI in order to inform current and future prevention, treatment, and healthcare utilization measures. [Image: see text] DISCLOSURES: N. Halasa, Sanofi Pasteur: Investigator, Research support. GSK: Consultant, Consulting fee. Moderna: Consultant, Consulting fee. J. Englund, Gilead: Consultant and Investigator, Consulting fee and Research support. Novavax: Investigator, Research support. GlaxoSmithKline: Investigator, Research support. Alios: Investigator, Research support. MedImmune: Investigator, Research support. J. V. Williams, Quidel: Board Member, Consulting fee. GlaxoSmithKline: Consultant, Consulting fee.
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spelling pubmed-62556432018-11-28 751. Acute Respiratory Illness Hospitalizations Among Young Children: Multi-Center Viral Surveillance Network, United States, 2015–2016 Rha, Brian Campbell, Angela P McDaniel, Darius Selvarangan, Rangaraj Halasa, Natasha Englund, Janet Boom, Julie A Azimi, Parvin H Weinberg, Geoffrey A Staat, Mary A Singer, Monica N Sahni, Leila C McNeal, Monica Klein, Eileen J Harrison, Christopher J Williams, John V Yu, Joana Figueroa-Downing, Daniella Prill, Mila M Whitaker, Brett L Curns, Aaron T Langley, Gayle E Payne, Daniel C Gerber, Susan I Open Forum Infect Dis Abstracts BACKGROUND: Viral infections are a significant cause of severe acute respiratory illnesses (ARI) in young children. Understanding the current epidemiology of these viruses is important for informing treatment and prevention measures. We describe the New Vaccine Surveillance Network (NVSN) and report preliminary results from 2015 to 2016. METHODS: Prospective active surveillance for hospitalized ARI was conducted from November 1, 2015 to June 30, 2016 among children <5 years of age at seven pediatric hospital sites (figure) using a broad case definition based on admission diagnoses. Parent interviews and medical chart reviews were performed, and mid-turbinate nasal and throat flocked swabs and/or tracheal aspirates were tested for adenovirus, human metapneumovirus (HMPV), influenza, parainfluenza viruses (PIV) 1–3, respiratory syncytial virus (RSV), and rhinovirus/enterovirus using molecular diagnostic assays at each site. Asymptomatic controls <5 years of age were also enrolled. RESULTS: Among 2,974 hospitalized children with ARI whose specimens were tested for viruses, 2,228 (75%) were <2 years old, with 745 (25%) 0–2 months, and 309 (10%) 3–5 months old. The majority were male (58%; n = 1,732) and 63% (n = 1,093) had no documented comorbid conditions. The median length of stay was 2 days; 1,683 (57%) received supplemental oxygen, 435 (15%) were admitted to intensive care, 95 (3%) required mechanical ventilation, and 1 (<1%) died. Viruses were detected in 2,242 (75%) children with ARI, with >1 virus detected in 234 (8%). RSV was detected in 1,039 (35%) children with ARI, HMPV in 245 (8%), influenza in 104 (4%), and PIV-1, PIV-2, and PIV-3 in 49 (2%), 2 (<1%), and 78 (3%), respectively. Rhinovirus/enterovirus was detected in 849 (29%) and adenovirus in 118 (4%) children with ARI, but were also detected in 18% (n = 227) and 5% (n = 60), respectively, of the 1,243 controls tested; the other viruses were more rarely detected in controls. CONCLUSION: During the 2015–2016 season, viral detections were common in young children hospitalized for ARI at seven US sites. NVSN combines clinical data with current molecular laboratory techniques to describe respiratory virus epidemiology in cases of hospitalized pediatric ARI in order to inform current and future prevention, treatment, and healthcare utilization measures. [Image: see text] DISCLOSURES: N. Halasa, Sanofi Pasteur: Investigator, Research support. GSK: Consultant, Consulting fee. Moderna: Consultant, Consulting fee. J. Englund, Gilead: Consultant and Investigator, Consulting fee and Research support. Novavax: Investigator, Research support. GlaxoSmithKline: Investigator, Research support. Alios: Investigator, Research support. MedImmune: Investigator, Research support. J. V. Williams, Quidel: Board Member, Consulting fee. GlaxoSmithKline: Consultant, Consulting fee. Oxford University Press 2018-11-26 /pmc/articles/PMC6255643/ http://dx.doi.org/10.1093/ofid/ofy210.758 Text en © The Author(s) 2018. Published by Oxford University Press on behalf of Infectious Diseases Society of America. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Abstracts
Rha, Brian
Campbell, Angela P
McDaniel, Darius
Selvarangan, Rangaraj
Halasa, Natasha
Englund, Janet
Boom, Julie A
Azimi, Parvin H
Weinberg, Geoffrey A
Staat, Mary A
Singer, Monica N
Sahni, Leila C
McNeal, Monica
Klein, Eileen J
Harrison, Christopher J
Williams, John V
Yu, Joana
Figueroa-Downing, Daniella
Prill, Mila M
Whitaker, Brett L
Curns, Aaron T
Langley, Gayle E
Payne, Daniel C
Gerber, Susan I
751. Acute Respiratory Illness Hospitalizations Among Young Children: Multi-Center Viral Surveillance Network, United States, 2015–2016
title 751. Acute Respiratory Illness Hospitalizations Among Young Children: Multi-Center Viral Surveillance Network, United States, 2015–2016
title_full 751. Acute Respiratory Illness Hospitalizations Among Young Children: Multi-Center Viral Surveillance Network, United States, 2015–2016
title_fullStr 751. Acute Respiratory Illness Hospitalizations Among Young Children: Multi-Center Viral Surveillance Network, United States, 2015–2016
title_full_unstemmed 751. Acute Respiratory Illness Hospitalizations Among Young Children: Multi-Center Viral Surveillance Network, United States, 2015–2016
title_short 751. Acute Respiratory Illness Hospitalizations Among Young Children: Multi-Center Viral Surveillance Network, United States, 2015–2016
title_sort 751. acute respiratory illness hospitalizations among young children: multi-center viral surveillance network, united states, 2015–2016
topic Abstracts
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6255643/
http://dx.doi.org/10.1093/ofid/ofy210.758
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