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Waveforms of molecular oscillations reveal circadian timekeeping mechanisms
Circadian clocks play a pivotal role in orchestrating numerous physiological and developmental events. Waveform shapes of the oscillations of protein abundances can be informative about the underlying biochemical processes of circadian clocks. We derive a mathematical framework where waveforms do re...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6255756/ https://www.ncbi.nlm.nih.gov/pubmed/30511021 http://dx.doi.org/10.1038/s42003-018-0217-1 |
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author | Jo, Hang-Hyun Kim, Yeon Jeong Kim, Jae Kyoung Foo, Mathias Somers, David E. Kim, Pan-Jun |
author_facet | Jo, Hang-Hyun Kim, Yeon Jeong Kim, Jae Kyoung Foo, Mathias Somers, David E. Kim, Pan-Jun |
author_sort | Jo, Hang-Hyun |
collection | PubMed |
description | Circadian clocks play a pivotal role in orchestrating numerous physiological and developmental events. Waveform shapes of the oscillations of protein abundances can be informative about the underlying biochemical processes of circadian clocks. We derive a mathematical framework where waveforms do reveal hidden biochemical mechanisms of circadian timekeeping. We find that the cost of synthesizing proteins with particular waveforms can be substantially reduced by rhythmic protein half-lives over time, as supported by previous plant and mammalian data, as well as our own seedling experiment. We also find that previously enigmatic, cyclic expression of positive arm components within the mammalian and insect clocks allows both a broad range of peak time differences between protein waveforms and the symmetries of the waveforms about the peak times. Such various peak-time differences may facilitate tissue-specific or developmental stage-specific multicellular processes. Our waveform-guided approach can be extended to various biological oscillators, including cell-cycle and synthetic genetic oscillators. |
format | Online Article Text |
id | pubmed-6255756 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-62557562018-12-03 Waveforms of molecular oscillations reveal circadian timekeeping mechanisms Jo, Hang-Hyun Kim, Yeon Jeong Kim, Jae Kyoung Foo, Mathias Somers, David E. Kim, Pan-Jun Commun Biol Article Circadian clocks play a pivotal role in orchestrating numerous physiological and developmental events. Waveform shapes of the oscillations of protein abundances can be informative about the underlying biochemical processes of circadian clocks. We derive a mathematical framework where waveforms do reveal hidden biochemical mechanisms of circadian timekeeping. We find that the cost of synthesizing proteins with particular waveforms can be substantially reduced by rhythmic protein half-lives over time, as supported by previous plant and mammalian data, as well as our own seedling experiment. We also find that previously enigmatic, cyclic expression of positive arm components within the mammalian and insect clocks allows both a broad range of peak time differences between protein waveforms and the symmetries of the waveforms about the peak times. Such various peak-time differences may facilitate tissue-specific or developmental stage-specific multicellular processes. Our waveform-guided approach can be extended to various biological oscillators, including cell-cycle and synthetic genetic oscillators. Nature Publishing Group UK 2018-11-26 /pmc/articles/PMC6255756/ /pubmed/30511021 http://dx.doi.org/10.1038/s42003-018-0217-1 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Jo, Hang-Hyun Kim, Yeon Jeong Kim, Jae Kyoung Foo, Mathias Somers, David E. Kim, Pan-Jun Waveforms of molecular oscillations reveal circadian timekeeping mechanisms |
title | Waveforms of molecular oscillations reveal circadian timekeeping mechanisms |
title_full | Waveforms of molecular oscillations reveal circadian timekeeping mechanisms |
title_fullStr | Waveforms of molecular oscillations reveal circadian timekeeping mechanisms |
title_full_unstemmed | Waveforms of molecular oscillations reveal circadian timekeeping mechanisms |
title_short | Waveforms of molecular oscillations reveal circadian timekeeping mechanisms |
title_sort | waveforms of molecular oscillations reveal circadian timekeeping mechanisms |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6255756/ https://www.ncbi.nlm.nih.gov/pubmed/30511021 http://dx.doi.org/10.1038/s42003-018-0217-1 |
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