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Enhanced anti-metastatic bioactivity of an IGF-TRAP re-engineered to improve physicochemical properties
The insulin-like growth factor (IGF) axis has been implicated in the progression of malignant disease and identified as a clinically important therapeutic target. Several IGF-1 receptor (IGF-1R) targeting drugs including humanized monoclonal antibodies have advanced to phase II/III clinical trials,...
| Autores principales: | , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6255772/ https://www.ncbi.nlm.nih.gov/pubmed/30478273 http://dx.doi.org/10.1038/s41598-018-35407-2 |