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Repurposing CRISPR-Cas12b for mammalian genome engineering

The prokaryotic CRISPR-Cas adaptive immune systems provide valuable resources to develop genome editing tools, such as CRISPR-Cas9 and CRISPR-Cas12a/Cpf1. Recently, CRISPR-Cas12b/C2c1, a distinct type V-B system, has been characterized as a dual-RNA-guided DNA endonuclease system. Though being activ...

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Detalles Bibliográficos
Autores principales:	Teng, Fei, Cui, Tongtong, Feng, Guihai, Guo, Lu, Xu, Kai, Gao, Qingqin, Li, Tianda, Li, Jing, Zhou, Qi, Li, Wei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6255809/ https://www.ncbi.nlm.nih.gov/pubmed/30510770 http://dx.doi.org/10.1038/s41421-018-0069-3

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