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Treatment outcome and associated factors among patients with epilepsy

Epilepsy is a major public health problem worldwide. Despite multiple drug therapies, people with epilepsy continue to have frequent seizures. There is a dearth of data on epilepsy treatment outcome and associated factors in our setting. Therefore, the aim of this was to assess treatment outcome and...

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Autores principales: Niriayo, Yirga Legesse, Mamo, Abraham, Kassa, Tesfaye Dessale, Asgedom, Solomon Weldegebreal, Atey, Tesfay Mahari, Gidey, Kidu, Demoz, Gebre Teklemariam, Ibrahim, Seid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6255833/
https://www.ncbi.nlm.nih.gov/pubmed/30478263
http://dx.doi.org/10.1038/s41598-018-35906-2
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author Niriayo, Yirga Legesse
Mamo, Abraham
Kassa, Tesfaye Dessale
Asgedom, Solomon Weldegebreal
Atey, Tesfay Mahari
Gidey, Kidu
Demoz, Gebre Teklemariam
Ibrahim, Seid
author_facet Niriayo, Yirga Legesse
Mamo, Abraham
Kassa, Tesfaye Dessale
Asgedom, Solomon Weldegebreal
Atey, Tesfay Mahari
Gidey, Kidu
Demoz, Gebre Teklemariam
Ibrahim, Seid
author_sort Niriayo, Yirga Legesse
collection PubMed
description Epilepsy is a major public health problem worldwide. Despite multiple drug therapies, people with epilepsy continue to have frequent seizures. There is a dearth of data on epilepsy treatment outcome and associated factors in our setting. Therefore, the aim of this was to assess treatment outcome and associated factors among epileptic patients on follow up at the neurologic clinic of Ayder comprehensive specialized hospital, Ethiopia. A cross-sectional study was conducted on randomly selected epileptic patients. Data were collected through patient interview and review of medical records. Epilepsy treatment outcome was evaluated in terms of seizure control status in the last one year follow up period. Binary logistic regression analysis was performed to identify predictors of treatment outcome. A total of 270 patients were included. Of whom, 46.6% had controlled seizures. Whereas, 38.5%, 8.8%, and 5.9% had experienced seizure attacks 1–5 times, 6–10 times, and greater than 10 times, respectively. Alcohol consumption [adjusted odds ratio [(AOR): 14.87, 95% confidence interval (CI): 3.25–68.11], negative medication belief [AOR: 3.0, 95%CI: 1.31–6.71], low medication adherence [AOR:11.52, 95%CI: 3.25–40.82], and presence of comorbidities [AOR: 10.35, 95%CI: 4.40–24.40] were predictors of uncontrolled seizure. Our finding revealed that more than half of the epileptic patients had uncontrolled seizure. Epileptic patients with a negative medication belief, comorbidities, low medication adherence, and those who consume alcohol were more likely to have uncontrolled seizure. Therefore, more emphasis should be given to these patients.
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spelling pubmed-62558332018-12-03 Treatment outcome and associated factors among patients with epilepsy Niriayo, Yirga Legesse Mamo, Abraham Kassa, Tesfaye Dessale Asgedom, Solomon Weldegebreal Atey, Tesfay Mahari Gidey, Kidu Demoz, Gebre Teklemariam Ibrahim, Seid Sci Rep Article Epilepsy is a major public health problem worldwide. Despite multiple drug therapies, people with epilepsy continue to have frequent seizures. There is a dearth of data on epilepsy treatment outcome and associated factors in our setting. Therefore, the aim of this was to assess treatment outcome and associated factors among epileptic patients on follow up at the neurologic clinic of Ayder comprehensive specialized hospital, Ethiopia. A cross-sectional study was conducted on randomly selected epileptic patients. Data were collected through patient interview and review of medical records. Epilepsy treatment outcome was evaluated in terms of seizure control status in the last one year follow up period. Binary logistic regression analysis was performed to identify predictors of treatment outcome. A total of 270 patients were included. Of whom, 46.6% had controlled seizures. Whereas, 38.5%, 8.8%, and 5.9% had experienced seizure attacks 1–5 times, 6–10 times, and greater than 10 times, respectively. Alcohol consumption [adjusted odds ratio [(AOR): 14.87, 95% confidence interval (CI): 3.25–68.11], negative medication belief [AOR: 3.0, 95%CI: 1.31–6.71], low medication adherence [AOR:11.52, 95%CI: 3.25–40.82], and presence of comorbidities [AOR: 10.35, 95%CI: 4.40–24.40] were predictors of uncontrolled seizure. Our finding revealed that more than half of the epileptic patients had uncontrolled seizure. Epileptic patients with a negative medication belief, comorbidities, low medication adherence, and those who consume alcohol were more likely to have uncontrolled seizure. Therefore, more emphasis should be given to these patients. Nature Publishing Group UK 2018-11-26 /pmc/articles/PMC6255833/ /pubmed/30478263 http://dx.doi.org/10.1038/s41598-018-35906-2 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Niriayo, Yirga Legesse
Mamo, Abraham
Kassa, Tesfaye Dessale
Asgedom, Solomon Weldegebreal
Atey, Tesfay Mahari
Gidey, Kidu
Demoz, Gebre Teklemariam
Ibrahim, Seid
Treatment outcome and associated factors among patients with epilepsy
title Treatment outcome and associated factors among patients with epilepsy
title_full Treatment outcome and associated factors among patients with epilepsy
title_fullStr Treatment outcome and associated factors among patients with epilepsy
title_full_unstemmed Treatment outcome and associated factors among patients with epilepsy
title_short Treatment outcome and associated factors among patients with epilepsy
title_sort treatment outcome and associated factors among patients with epilepsy
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6255833/
https://www.ncbi.nlm.nih.gov/pubmed/30478263
http://dx.doi.org/10.1038/s41598-018-35906-2
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