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Adaptive hindlimb split-belt treadmill walking in rats by controlling basic muscle activation patterns via phase resetting

To investigate the adaptive locomotion mechanism in animals, a split-belt treadmill has been used, which has two parallel belts to produce left–right symmetric and asymmetric environments for walking. Spinal cats walking on the treadmill have suggested the contribution of the spinal cord and associa...

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Autores principales: Fujiki, Soichiro, Aoi, Shinya, Funato, Tetsuro, Sato, Yota, Tsuchiya, Kazuo, Yanagihara, Dai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6255885/
https://www.ncbi.nlm.nih.gov/pubmed/30478405
http://dx.doi.org/10.1038/s41598-018-35714-8
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author Fujiki, Soichiro
Aoi, Shinya
Funato, Tetsuro
Sato, Yota
Tsuchiya, Kazuo
Yanagihara, Dai
author_facet Fujiki, Soichiro
Aoi, Shinya
Funato, Tetsuro
Sato, Yota
Tsuchiya, Kazuo
Yanagihara, Dai
author_sort Fujiki, Soichiro
collection PubMed
description To investigate the adaptive locomotion mechanism in animals, a split-belt treadmill has been used, which has two parallel belts to produce left–right symmetric and asymmetric environments for walking. Spinal cats walking on the treadmill have suggested the contribution of the spinal cord and associated peripheral nervous system to the adaptive locomotion. Physiological studies have shown that phase resetting of locomotor commands involving a phase shift occurs depending on the types of sensory nerves and stimulation timing, and that muscle activation patterns during walking are represented by a linear combination of a few numbers of basic temporal patterns despite the complexity of the activation patterns. Our working hypothesis was that resetting the onset timings of basic temporal patterns based on the sensory information from the leg, especially extension of hip flexors, contributes to adaptive locomotion on the split-belt treadmill. Our hypothesis was examined by conducting forward dynamic simulations using a neuromusculoskeletal model of a rat walking on a split-belt treadmill with its hindlimbs and by comparing the simulated motions with the measured motions of rats.
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spelling pubmed-62558852018-12-03 Adaptive hindlimb split-belt treadmill walking in rats by controlling basic muscle activation patterns via phase resetting Fujiki, Soichiro Aoi, Shinya Funato, Tetsuro Sato, Yota Tsuchiya, Kazuo Yanagihara, Dai Sci Rep Article To investigate the adaptive locomotion mechanism in animals, a split-belt treadmill has been used, which has two parallel belts to produce left–right symmetric and asymmetric environments for walking. Spinal cats walking on the treadmill have suggested the contribution of the spinal cord and associated peripheral nervous system to the adaptive locomotion. Physiological studies have shown that phase resetting of locomotor commands involving a phase shift occurs depending on the types of sensory nerves and stimulation timing, and that muscle activation patterns during walking are represented by a linear combination of a few numbers of basic temporal patterns despite the complexity of the activation patterns. Our working hypothesis was that resetting the onset timings of basic temporal patterns based on the sensory information from the leg, especially extension of hip flexors, contributes to adaptive locomotion on the split-belt treadmill. Our hypothesis was examined by conducting forward dynamic simulations using a neuromusculoskeletal model of a rat walking on a split-belt treadmill with its hindlimbs and by comparing the simulated motions with the measured motions of rats. Nature Publishing Group UK 2018-11-26 /pmc/articles/PMC6255885/ /pubmed/30478405 http://dx.doi.org/10.1038/s41598-018-35714-8 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Fujiki, Soichiro
Aoi, Shinya
Funato, Tetsuro
Sato, Yota
Tsuchiya, Kazuo
Yanagihara, Dai
Adaptive hindlimb split-belt treadmill walking in rats by controlling basic muscle activation patterns via phase resetting
title Adaptive hindlimb split-belt treadmill walking in rats by controlling basic muscle activation patterns via phase resetting
title_full Adaptive hindlimb split-belt treadmill walking in rats by controlling basic muscle activation patterns via phase resetting
title_fullStr Adaptive hindlimb split-belt treadmill walking in rats by controlling basic muscle activation patterns via phase resetting
title_full_unstemmed Adaptive hindlimb split-belt treadmill walking in rats by controlling basic muscle activation patterns via phase resetting
title_short Adaptive hindlimb split-belt treadmill walking in rats by controlling basic muscle activation patterns via phase resetting
title_sort adaptive hindlimb split-belt treadmill walking in rats by controlling basic muscle activation patterns via phase resetting
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6255885/
https://www.ncbi.nlm.nih.gov/pubmed/30478405
http://dx.doi.org/10.1038/s41598-018-35714-8
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