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Identification of a Small Interface between the Methyltransferase and RNA Polymerase of NS5 that is Essential for Zika Virus Replication

The spread of Zika virus (ZIKV) has caused an international health emergency due to its ability to cause microcephaly in infants. Yet, our knowledge of how ZIKV replicates at the molecular level is limited. For example, how the non-structural protein 5 (NS5) performs replication, and in particular w...

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Detalles Bibliográficos
Autores principales:	Rusanov, Timur, Kent, Tatiana, Saeed, Mohsan, Hoang, Trung M., Thomas, Crystal, Rice, Charles M., Pomerantz, Richard T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6255901/ https://www.ncbi.nlm.nih.gov/pubmed/30478404 http://dx.doi.org/10.1038/s41598-018-35511-3

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