Cryo-EM structures of KdpFABC suggest a K(+) transport mechanism via two inter-subunit half-channels

P-type ATPases ubiquitously pump cations across biological membranes to maintain vital ion gradients. Among those, the chimeric K(+) uptake system KdpFABC is unique. While ATP hydrolysis is accomplished by the P-type ATPase subunit KdpB, K(+) has been assumed to be transported by the channel-like su...

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Detalles Bibliográficos
Autores principales: Stock, C., Hielkema, L., Tascón, I., Wunnicke, D., Oostergetel, G. T., Azkargorta, M., Paulino, C., Hänelt, I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6255902/
https://www.ncbi.nlm.nih.gov/pubmed/30478378
http://dx.doi.org/10.1038/s41467-018-07319-2

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