Cargando…

Interplay between hypoxia and androgen controls a metabolic switch conferring resistance to androgen/AR-targeted therapy

Despite recent advances, the efficacy of androgen/androgen receptor (AR)-targeted therapy remains limited for many patients with metastatic prostate cancer. This is in part because prostate cancers adaptively switch to the androgen/AR-independent pathway for survival and growth, thereby conferring...

Descripción completa

Detalles Bibliográficos
Autores principales:	Geng, Hao, Xue, Changhui, Mendonca, Janet, Sun, Xiao-Xin, Liu, Qiong, Reardon, Patrick N., Chen, Yingxiao, Qian, Kendrick, Hua, Vivian, Chen, Alice, Pan, Freddy, Yuan, Julia, Dang, Sang, Beer, Tomasz M., Dai, Mu-Shui, Kachhap, Sushant K., Qian, David Z.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6255907/ https://www.ncbi.nlm.nih.gov/pubmed/30478344 http://dx.doi.org/10.1038/s41467-018-07411-7

Ejemplares similares

Publisher Correction: Interplay between hypoxia and androgen controls a metabolic switch conferring resistance to androgen/AR-targeted therapy
por: Geng, Hao, et al.
Publicado: (2019)

HIF1 and ID1 Interplay Confers Adaptive Survival to HIF1α-Inhibition
por: Geng, Hao, et al.
Publicado: (2021)

Racial Differences in Androgen Receptor (AR) and AR Splice Variants (AR-SVs) Expression in Treatment-Naïve Androgen-Dependent Prostate Cancer
por: Khan, Farhan, et al.
Publicado: (2023)

Diverse roles of androgen receptor (AR) domains in AR-mediated signaling
por: Claessens, Frank, et al.
Publicado: (2008)

Therapeutic targeting of the androgen receptor (AR) and AR variants in prostate cancer
por: Narayanan, Ramesh
Publicado: (2020)

Identification of an AR Mutation-Negative Class of Androgen Insensitivity by Determining Endogenous AR Activity
por: Hornig, N. C., et al.
Publicado: (2016)

From AR to c-Met: Androgen deprivation leads to a signaling pathway switch in prostate cancer cells
por: LIU, TIANCHENG, et al.
Publicado: ( 201)

Androgen receptor activity in prostate cancer dictates efficacy of bipolar androgen therapy through MYC
por: Sena, Laura A., et al.
Publicado: (2022)

Androgen-Sensitized Apoptosis of HPr-1AR Human Prostate Epithelial Cells
por: Chen, Congcong, et al.
Publicado: (2016)

Contribution of allelic variability in prostate specific antigen (PSA) & androgen receptor (AR) genes to serum PSA levels in men with prostate cancer
por: Chavan, Sushant V., et al.
Publicado: (2014)

Androgens and Androgen Receptor Actions on Bone Health and Disease: From Androgen Deficiency to Androgen Therapy
por: Chen, Jia-Feng, et al.
Publicado: (2019)

Baicalein suppresses the androgen receptor (AR)-mediated prostate cancer progression via inhibiting the AR N-C dimerization and AR-coactivators interaction
por: Xu, Defeng, et al.
Publicado: (2017)

Immunohistochemical Expression of Androgen Receptors (AR) in Various Breast Cancer Subtypes
por: Ismael, Nour El Hoda S., et al.
Publicado: (2019)

Regulation of androgen receptor splice variant AR3 by PCGEM1
por: Zhang, Ziqiang, et al.
Publicado: (2016)

Sex, androgens and regulation of pulmonary AR, TMPRSS2 and ACE2
por: Baratchian, Mehdi, et al.
Publicado: (2020)

Drivers of AR indifferent anti-androgen resistance in prostate cancer cells
por: Handle, Florian, et al.
Publicado: (2019)

Androgen Receptor-Mediated Growth Suppression of HPr-1AR and PC3-Lenti-AR Prostate Epithelial Cells
por: Kim, Young-Chae, et al.
Publicado: (2015)

Androgen receptor (AR) antagonism triggers acute succinate‐mediated adaptive responses to reactivate AR signaling
por: Saxena, Neetu, et al.
Publicado: (2021)

Correction: Androgen-Sensitized Apoptosis of HPr-1AR Human Prostate Epithelial Cells
por: Chen, Congcong, et al.
Publicado: (2019)

Detection of androgen receptor (AR) and AR-V7 in small cell prostate carcinoma: Diagnostic and therapeutic implications
por: Zhao, Pei, et al.
Publicado: (2019)

Dual androgen receptor (AR) and STAT3 inhibition by a compound targeting the AR amino‐terminal domain
por: Hua, Yaping, et al.
Publicado: (2018)

Androgens and Adipose Tissue in Males: A Complex and Reciprocal Interplay
por: Mammi, Caterina, et al.
Publicado: (2012)

The interplay between androgens and the immune response in polycystic ovary syndrome
por: Shabbir, Sania, et al.
Publicado: (2023)

Androgen receptor splice variants circumvent AR blockade by microtubule-targeting agents
por: Zhang, Guanyi, et al.
Publicado: (2015)

Destroying the androgen receptor (AR)-potential strategy to treat advanced prostate cancer
por: Narayanan, Ramesh, et al.
Publicado: (2017)

Chemical Degradation of Androgen Receptor (AR) Using Bicalutamide Analog–Thalidomide PROTACs
por: Kim, Ga Yeong, et al.
Publicado: (2021)

High-throughput AR dimerization assay identifies androgen disrupting chemicals and metabolites
por: Brown, Evan C., et al.
Publicado: (2023)

Androgen receptor (AR) pathophysiological roles in androgen-related diseases in skin, bone/muscle, metabolic syndrome and neuron/immune systems: lessons learned from mice lacking AR in specific cells
por: Chang, Chawnshang, et al.
Publicado: (2013)

The Worldwide Landscape of Variants in the Androgen Receptor Gene Related to Androgen Insensitivity Syndrome: An Integrative Analysis
por: Batista, Rafael Loch, et al.
Publicado: (2021)

Computational analysis of androgen receptor (AR) variants to decipher the relationship between protein stability and related-diseases
por: Chen, Fangfang, et al.
Publicado: (2020)

Androgen regulation of the androgen receptor coregulators
por: Urbanucci, Alfonso, et al.
Publicado: (2008)

Role of androgen receptor splice variant 7 (AR-V7) in prostate cancer resistance to 2(nd) generation androgen receptor signaling inhibitors
por: Zhu, Yezi, et al.
Publicado: (2020)

Direct Interaction between AR and PAK6 in Androgen-Stimulated PAK6 Activation
por: Liu, Xia, et al.
Publicado: (2013)

Immune Modulation in Prostate Cancer Patients Treated with Androgen Receptor (AR)-Targeted Therapy
por: Conteduca, Vincenza, et al.
Publicado: (2020)

Nonmalignant AR-positive prostate epithelial cells and cancer cells respond differently to androgen
por: Kukkonen, Konsta, et al.
Publicado: (2022)

KLF9 suppresses cell growth and induces apoptosis via the AR pathway in androgen-dependent prostate cancer cells
por: Shen, Pengliang, et al.
Publicado: (2021)

Hedgehog/Gli supports androgen signaling in androgen deprived and androgen independent prostate cancer cells
por: Chen, Mengqian, et al.
Publicado: (2010)

Association between prenatal androgens and cord blood androgens, a path analysis
por: Xu, Hui, et al.
Publicado: (2023)

Stilbene Induced Inhibition of Androgen Receptor Dimerization: Implications for AR and ARΔLBD-Signalling in Human Prostate Cancer Cells
por: Streicher, Wolfgang, et al.
Publicado: (2014)

CCAR1 promotes chromatin loading of androgen receptor (AR) transcription complex by stabilizing the association between AR and GATA2
por: Seo, Woo-Young, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_c1of73fug3bffrmr67nq15qvd4