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Lymphoid Stress Surveillance Response Contributes to Vitiligo Pathogenesis
Vitiligo is a chronic multifactorial depigmentation disorder characterized by the destruction and functional loss of melanocytes. Although a direct cytotoxic T cell attack is thought to be responsible for melanocyte damage, the events leading to the loss of self-tolerance toward melanocytic antigens...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6255962/ https://www.ncbi.nlm.nih.gov/pubmed/30515176 http://dx.doi.org/10.3389/fimmu.2018.02707 |
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author | Raam, Liisi Kaleviste, Epp Šunina, Marina Vaher, Helen Saare, Mario Prans, Ele Pihlap, Maire Abram, Kristi Karelson, Maire Peterson, Pärt Rebane, Ana Kisand, Kai Kingo, Külli |
author_facet | Raam, Liisi Kaleviste, Epp Šunina, Marina Vaher, Helen Saare, Mario Prans, Ele Pihlap, Maire Abram, Kristi Karelson, Maire Peterson, Pärt Rebane, Ana Kisand, Kai Kingo, Külli |
author_sort | Raam, Liisi |
collection | PubMed |
description | Vitiligo is a chronic multifactorial depigmentation disorder characterized by the destruction and functional loss of melanocytes. Although a direct cytotoxic T cell attack is thought to be responsible for melanocyte damage, the events leading to the loss of self-tolerance toward melanocytic antigens are not understood. This research aimed to identify novel cellular and molecular factors that participate in vitiligo pathogenesis through the application of gene expression and immunofluorescence analysis of skin biopsy samples along with immunophenotyping of circulating cells. Our study provides insights into the mechanisms involved in melanocyte destruction. The upregulation of stress-ligand MICA/MICB, recognized by activating receptors on innate and innate-like T cells, imply involvement of lymphoid stress surveillance responses in vitiligo lesions. A simultaneous increase in the expression of transcription factor EOMES that is characteristic for innate-like virtual memory T cells, suggest a similar scenario. Local lymphoid stress surveillance has been previously associated with the amplification of systemic humoral responses that were mirrored in our study by increased T follicular helper cells and switched memory B cell proportions in patients with active vitiligo. In addition, microtubule-associated protein light chain 3 staining was compatible with the activation of autophagy in keratinocytes and in the remaining melanocytes of vitiligo lesional skin. |
format | Online Article Text |
id | pubmed-6255962 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-62559622018-12-04 Lymphoid Stress Surveillance Response Contributes to Vitiligo Pathogenesis Raam, Liisi Kaleviste, Epp Šunina, Marina Vaher, Helen Saare, Mario Prans, Ele Pihlap, Maire Abram, Kristi Karelson, Maire Peterson, Pärt Rebane, Ana Kisand, Kai Kingo, Külli Front Immunol Immunology Vitiligo is a chronic multifactorial depigmentation disorder characterized by the destruction and functional loss of melanocytes. Although a direct cytotoxic T cell attack is thought to be responsible for melanocyte damage, the events leading to the loss of self-tolerance toward melanocytic antigens are not understood. This research aimed to identify novel cellular and molecular factors that participate in vitiligo pathogenesis through the application of gene expression and immunofluorescence analysis of skin biopsy samples along with immunophenotyping of circulating cells. Our study provides insights into the mechanisms involved in melanocyte destruction. The upregulation of stress-ligand MICA/MICB, recognized by activating receptors on innate and innate-like T cells, imply involvement of lymphoid stress surveillance responses in vitiligo lesions. A simultaneous increase in the expression of transcription factor EOMES that is characteristic for innate-like virtual memory T cells, suggest a similar scenario. Local lymphoid stress surveillance has been previously associated with the amplification of systemic humoral responses that were mirrored in our study by increased T follicular helper cells and switched memory B cell proportions in patients with active vitiligo. In addition, microtubule-associated protein light chain 3 staining was compatible with the activation of autophagy in keratinocytes and in the remaining melanocytes of vitiligo lesional skin. Frontiers Media S.A. 2018-11-20 /pmc/articles/PMC6255962/ /pubmed/30515176 http://dx.doi.org/10.3389/fimmu.2018.02707 Text en Copyright © 2018 Raam, Kaleviste, Šunina, Vaher, Saare, Prans, Pihlap, Abram, Karelson, Peterson, Rebane, Kisand and Kingo. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Raam, Liisi Kaleviste, Epp Šunina, Marina Vaher, Helen Saare, Mario Prans, Ele Pihlap, Maire Abram, Kristi Karelson, Maire Peterson, Pärt Rebane, Ana Kisand, Kai Kingo, Külli Lymphoid Stress Surveillance Response Contributes to Vitiligo Pathogenesis |
title | Lymphoid Stress Surveillance Response Contributes to Vitiligo Pathogenesis |
title_full | Lymphoid Stress Surveillance Response Contributes to Vitiligo Pathogenesis |
title_fullStr | Lymphoid Stress Surveillance Response Contributes to Vitiligo Pathogenesis |
title_full_unstemmed | Lymphoid Stress Surveillance Response Contributes to Vitiligo Pathogenesis |
title_short | Lymphoid Stress Surveillance Response Contributes to Vitiligo Pathogenesis |
title_sort | lymphoid stress surveillance response contributes to vitiligo pathogenesis |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6255962/ https://www.ncbi.nlm.nih.gov/pubmed/30515176 http://dx.doi.org/10.3389/fimmu.2018.02707 |
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