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A Review on the Synthesis and Bioactivity Aspects of Beauvericin, a Fusarium Mycotoxin

Beauvericin (BEA) is an emerging Fusarium mycotoxin that contaminates food and feeds globally. BEA biosynthesis is rapidly catalyzed by BEA synthetase through a nonribosomal, thiol-templated mechanism. This mycotoxin has cytotoxicity and is capable of increasing oxidative stress to induce cell apopt...

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Autores principales: Wu, Qinghua, Patocka, Jiri, Nepovimova, Eugenie, Kuca, Kamil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6256083/
https://www.ncbi.nlm.nih.gov/pubmed/30515098
http://dx.doi.org/10.3389/fphar.2018.01338
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author Wu, Qinghua
Patocka, Jiri
Nepovimova, Eugenie
Kuca, Kamil
author_facet Wu, Qinghua
Patocka, Jiri
Nepovimova, Eugenie
Kuca, Kamil
author_sort Wu, Qinghua
collection PubMed
description Beauvericin (BEA) is an emerging Fusarium mycotoxin that contaminates food and feeds globally. BEA biosynthesis is rapidly catalyzed by BEA synthetase through a nonribosomal, thiol-templated mechanism. This mycotoxin has cytotoxicity and is capable of increasing oxidative stress to induce cell apoptosis. Recently, large evidence further shows that this mycotoxin has a variety of biological activities and is being considered a potential candidate for medicinal and pesticide research. It is noteworthy that BEA is a potential anticancer agent since it can increase the intracellular Ca(2+) levels and induce the cancer cell death through oxidative stress and apoptosis. BEA has exhibited effective antibacterial activities against both pathogenic Gram-positive and Gram-negative bacteria. Importantly, BEA exhibits an effective capacity to inhibit the human immunodeficiency virus type-1 integrase. Moreover, BEA can simultaneously target drug resistance and morphogenesis which provides a promising strategy to combat life-threatening fungal infections. Thus, in this review, the synthesis and the biological activities of BEA, as well as, the underlying mechanisms, are fully analyzed. The risk assessment of BEA in food and feed are also discussed. We hope this review will help to further understand the biological activities of BEA and cast some new light on drug discovery.
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spelling pubmed-62560832018-12-04 A Review on the Synthesis and Bioactivity Aspects of Beauvericin, a Fusarium Mycotoxin Wu, Qinghua Patocka, Jiri Nepovimova, Eugenie Kuca, Kamil Front Pharmacol Pharmacology Beauvericin (BEA) is an emerging Fusarium mycotoxin that contaminates food and feeds globally. BEA biosynthesis is rapidly catalyzed by BEA synthetase through a nonribosomal, thiol-templated mechanism. This mycotoxin has cytotoxicity and is capable of increasing oxidative stress to induce cell apoptosis. Recently, large evidence further shows that this mycotoxin has a variety of biological activities and is being considered a potential candidate for medicinal and pesticide research. It is noteworthy that BEA is a potential anticancer agent since it can increase the intracellular Ca(2+) levels and induce the cancer cell death through oxidative stress and apoptosis. BEA has exhibited effective antibacterial activities against both pathogenic Gram-positive and Gram-negative bacteria. Importantly, BEA exhibits an effective capacity to inhibit the human immunodeficiency virus type-1 integrase. Moreover, BEA can simultaneously target drug resistance and morphogenesis which provides a promising strategy to combat life-threatening fungal infections. Thus, in this review, the synthesis and the biological activities of BEA, as well as, the underlying mechanisms, are fully analyzed. The risk assessment of BEA in food and feed are also discussed. We hope this review will help to further understand the biological activities of BEA and cast some new light on drug discovery. Frontiers Media S.A. 2018-11-20 /pmc/articles/PMC6256083/ /pubmed/30515098 http://dx.doi.org/10.3389/fphar.2018.01338 Text en Copyright © 2018 Wu, Patocka, Nepovimova and Kuca. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Wu, Qinghua
Patocka, Jiri
Nepovimova, Eugenie
Kuca, Kamil
A Review on the Synthesis and Bioactivity Aspects of Beauvericin, a Fusarium Mycotoxin
title A Review on the Synthesis and Bioactivity Aspects of Beauvericin, a Fusarium Mycotoxin
title_full A Review on the Synthesis and Bioactivity Aspects of Beauvericin, a Fusarium Mycotoxin
title_fullStr A Review on the Synthesis and Bioactivity Aspects of Beauvericin, a Fusarium Mycotoxin
title_full_unstemmed A Review on the Synthesis and Bioactivity Aspects of Beauvericin, a Fusarium Mycotoxin
title_short A Review on the Synthesis and Bioactivity Aspects of Beauvericin, a Fusarium Mycotoxin
title_sort review on the synthesis and bioactivity aspects of beauvericin, a fusarium mycotoxin
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6256083/
https://www.ncbi.nlm.nih.gov/pubmed/30515098
http://dx.doi.org/10.3389/fphar.2018.01338
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