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Incidence and Antifungal Susceptibility of Candida Albicans Infections

ABSTRACT: INTRODUCTION. Candida albicans is the most common inhabitant of the skin, mouth, vagina and gastro intestinal tract of human beings. One of the major reasons for the increase in Candida infection is the development of its resistant strains due to drugs used in the treatment of candidiasis....

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Autores principales: UNGUREANU, A., GAMAN, A.E., TURCULEANU, A., MITROI, M., DROCAS, A.I., DOBRITOIU, M., ALEXANDRU, D.O., VASILE, C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medical University Publishing House Craiova 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6256162/
https://www.ncbi.nlm.nih.gov/pubmed/30568828
http://dx.doi.org/10.12865/CHSJ.42.02.08
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author UNGUREANU, A.
GAMAN, A.E.
TURCULEANU, A.
MITROI, M.
DROCAS, A.I.
DOBRITOIU, M.
ALEXANDRU, D.O.
VASILE, C.
author_facet UNGUREANU, A.
GAMAN, A.E.
TURCULEANU, A.
MITROI, M.
DROCAS, A.I.
DOBRITOIU, M.
ALEXANDRU, D.O.
VASILE, C.
author_sort UNGUREANU, A.
collection PubMed
description ABSTRACT: INTRODUCTION. Candida albicans is the most common inhabitant of the skin, mouth, vagina and gastro intestinal tract of human beings. One of the major reasons for the increase in Candida infection is the development of its resistant strains due to drugs used in the treatment of candidiasis. MATERIALS AND METHODS We studied 4027 samples collected from patients in various wards of the Emergency County Hospital Craiova, Romania between 2014-2015. The specimens were: pharyngeal exsudates, sputum, tracheal secretions, skin secretions, stools, ear secretions, urine, vaginal secretions. All the specimens were transported to the microbiology laboratory and cultured within 3 to 4 h of collection. Among the 4027 samples, 652 showed culture characteristics similar to Candida albicans.The samples were inoculated under sterile conditions using Sabouraud culture media, a medium designed to inhibit bacterial growth and allow the development of fungi. Antifungal Susceptibility Testing was performed by disc diffusion according to CLSI 2014 guidelines using: clotrimazole, ketoconazole, miconazole, econazole, amphotericine B, fluorocytozine, nistatin. RESULTS AND DISCUSSION In our study group the urocultures and dermatological products have a high infection rate, between 100% to 70%, in contrast, we find evidence of secretion ear (3.13%) and the throat swab (9.33%). Various resistant levels were detected against antifungal drugs but, complete resistance to 5 – Fluorocitozina (100%), and the organisms showed highly sensitive to Cotrimazol şi Ketoconazol (100%). In the case of Miconazol 256 (39, 26%), Econazol, 215 (32,98%), Amphotericinei B, 230(35,28%). Nystatin 329 (50,46%). CONCLUSIONSElucidating these mechanisms may provide new foundations for antifungal chemotherapy and can present an exciting challenge for the future investigations. Candida albicans infections are present and diverse clinical pathology.
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spelling pubmed-62561622018-12-19 Incidence and Antifungal Susceptibility of Candida Albicans Infections UNGUREANU, A. GAMAN, A.E. TURCULEANU, A. MITROI, M. DROCAS, A.I. DOBRITOIU, M. ALEXANDRU, D.O. VASILE, C. Curr Health Sci J Original Paper ABSTRACT: INTRODUCTION. Candida albicans is the most common inhabitant of the skin, mouth, vagina and gastro intestinal tract of human beings. One of the major reasons for the increase in Candida infection is the development of its resistant strains due to drugs used in the treatment of candidiasis. MATERIALS AND METHODS We studied 4027 samples collected from patients in various wards of the Emergency County Hospital Craiova, Romania between 2014-2015. The specimens were: pharyngeal exsudates, sputum, tracheal secretions, skin secretions, stools, ear secretions, urine, vaginal secretions. All the specimens were transported to the microbiology laboratory and cultured within 3 to 4 h of collection. Among the 4027 samples, 652 showed culture characteristics similar to Candida albicans.The samples were inoculated under sterile conditions using Sabouraud culture media, a medium designed to inhibit bacterial growth and allow the development of fungi. Antifungal Susceptibility Testing was performed by disc diffusion according to CLSI 2014 guidelines using: clotrimazole, ketoconazole, miconazole, econazole, amphotericine B, fluorocytozine, nistatin. RESULTS AND DISCUSSION In our study group the urocultures and dermatological products have a high infection rate, between 100% to 70%, in contrast, we find evidence of secretion ear (3.13%) and the throat swab (9.33%). Various resistant levels were detected against antifungal drugs but, complete resistance to 5 – Fluorocitozina (100%), and the organisms showed highly sensitive to Cotrimazol şi Ketoconazol (100%). In the case of Miconazol 256 (39, 26%), Econazol, 215 (32,98%), Amphotericinei B, 230(35,28%). Nystatin 329 (50,46%). CONCLUSIONSElucidating these mechanisms may provide new foundations for antifungal chemotherapy and can present an exciting challenge for the future investigations. Candida albicans infections are present and diverse clinical pathology. Medical University Publishing House Craiova 2016 2016-06-28 /pmc/articles/PMC6256162/ /pubmed/30568828 http://dx.doi.org/10.12865/CHSJ.42.02.08 Text en Copyright © 2016, Medical University Publishing House Craiova http://creativecommons.org/licenses/by-nc-sa/4.0/ This is an open-access article distributed under the terms of a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International Public License, which permits unrestricted use, adaptation, distribution and reproduction in any medium, non-commercially, provided the new creations are licensed under identical terms as the original work and the original work is properly cited.
spellingShingle Original Paper
UNGUREANU, A.
GAMAN, A.E.
TURCULEANU, A.
MITROI, M.
DROCAS, A.I.
DOBRITOIU, M.
ALEXANDRU, D.O.
VASILE, C.
Incidence and Antifungal Susceptibility of Candida Albicans Infections
title Incidence and Antifungal Susceptibility of Candida Albicans Infections
title_full Incidence and Antifungal Susceptibility of Candida Albicans Infections
title_fullStr Incidence and Antifungal Susceptibility of Candida Albicans Infections
title_full_unstemmed Incidence and Antifungal Susceptibility of Candida Albicans Infections
title_short Incidence and Antifungal Susceptibility of Candida Albicans Infections
title_sort incidence and antifungal susceptibility of candida albicans infections
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6256162/
https://www.ncbi.nlm.nih.gov/pubmed/30568828
http://dx.doi.org/10.12865/CHSJ.42.02.08
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