Cargando…
The Benefits of Neuromuscular Electrical Stimulation in the Muscular and Functional Capacity of Patients With Liver Cirrhosis: Protocol for a Randomized Clinical Trial
Cirrhosis causes systemic and metabolic changes that culminate in various complications, such as compromised pulmonary function, ascites, hepatic encephalopathy, weight loss, and muscle weakness with significant physical function limitations. Our aim is to evaluate the effects of training with neuro...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6256309/ https://www.ncbi.nlm.nih.gov/pubmed/30505152 http://dx.doi.org/10.1177/1179552218811834 |
_version_ | 1783374119852572672 |
---|---|
author | de Mello, Carolina Luana da Conceição, Thaís Martins Albanaz Dal Pont, Tarcila Peruzzolo, Catherine Corrêa Lúcio, Mariana Nunes Paulin, Elaine |
author_facet | de Mello, Carolina Luana da Conceição, Thaís Martins Albanaz Dal Pont, Tarcila Peruzzolo, Catherine Corrêa Lúcio, Mariana Nunes Paulin, Elaine |
author_sort | de Mello, Carolina Luana |
collection | PubMed |
description | Cirrhosis causes systemic and metabolic changes that culminate in various complications, such as compromised pulmonary function, ascites, hepatic encephalopathy, weight loss, and muscle weakness with significant physical function limitations. Our aim is to evaluate the effects of training with neuromuscular electrical stimulation (NMES) on the muscular and functional capacity of patients with cirrhosis classified as Child-Pugh B and C. A total of 72 patients diagnosed with cirrhosis will be recruited and randomized to perform an NMES protocol for 50 minutes, 3 times a week, for 4 weeks. The evaluations will be performed at the beginning and after 12 sessions, and patients will be submitted to a pulmonary function test, an ultrasound evaluation of the rectus femoris, an evaluation of peripheral muscle strength, a submaximal exercise capacity test associated with an evaluation of peripheral tissue oxygenation, a quality of life evaluation, and orientation about monitoring daily physical activities. The evaluators and patients will be blinded to the allocation of the groups. Training Group will be treated with the following parameters: frequency of 50 Hz, pulse width of 400 μs, rise and fall times of 2 s, and on:off 1:1; Sham Group: 5 Hz, 100 μs, on:off 1:3. The data will be analyzed using the principles of the intention to treat. This study provides health professionals with information on the benefits of this intervention. In this way, we believe that the results of this study could stimulate the use of NMES as a way of rehabilitating patients with more severe cirrhosis, with the objective of improving these patients’ functional independence. |
format | Online Article Text |
id | pubmed-6256309 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-62563092018-11-30 The Benefits of Neuromuscular Electrical Stimulation in the Muscular and Functional Capacity of Patients With Liver Cirrhosis: Protocol for a Randomized Clinical Trial de Mello, Carolina Luana da Conceição, Thaís Martins Albanaz Dal Pont, Tarcila Peruzzolo, Catherine Corrêa Lúcio, Mariana Nunes Paulin, Elaine Clin Med Insights Gastroenterol Study Protocol Cirrhosis causes systemic and metabolic changes that culminate in various complications, such as compromised pulmonary function, ascites, hepatic encephalopathy, weight loss, and muscle weakness with significant physical function limitations. Our aim is to evaluate the effects of training with neuromuscular electrical stimulation (NMES) on the muscular and functional capacity of patients with cirrhosis classified as Child-Pugh B and C. A total of 72 patients diagnosed with cirrhosis will be recruited and randomized to perform an NMES protocol for 50 minutes, 3 times a week, for 4 weeks. The evaluations will be performed at the beginning and after 12 sessions, and patients will be submitted to a pulmonary function test, an ultrasound evaluation of the rectus femoris, an evaluation of peripheral muscle strength, a submaximal exercise capacity test associated with an evaluation of peripheral tissue oxygenation, a quality of life evaluation, and orientation about monitoring daily physical activities. The evaluators and patients will be blinded to the allocation of the groups. Training Group will be treated with the following parameters: frequency of 50 Hz, pulse width of 400 μs, rise and fall times of 2 s, and on:off 1:1; Sham Group: 5 Hz, 100 μs, on:off 1:3. The data will be analyzed using the principles of the intention to treat. This study provides health professionals with information on the benefits of this intervention. In this way, we believe that the results of this study could stimulate the use of NMES as a way of rehabilitating patients with more severe cirrhosis, with the objective of improving these patients’ functional independence. SAGE Publications 2018-11-26 /pmc/articles/PMC6256309/ /pubmed/30505152 http://dx.doi.org/10.1177/1179552218811834 Text en © The Author(s) 2018 http://www.creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Study Protocol de Mello, Carolina Luana da Conceição, Thaís Martins Albanaz Dal Pont, Tarcila Peruzzolo, Catherine Corrêa Lúcio, Mariana Nunes Paulin, Elaine The Benefits of Neuromuscular Electrical Stimulation in the Muscular and Functional Capacity of Patients With Liver Cirrhosis: Protocol for a Randomized Clinical Trial |
title | The Benefits of Neuromuscular Electrical Stimulation in the Muscular
and Functional Capacity of Patients With Liver Cirrhosis: Protocol for a
Randomized Clinical Trial |
title_full | The Benefits of Neuromuscular Electrical Stimulation in the Muscular
and Functional Capacity of Patients With Liver Cirrhosis: Protocol for a
Randomized Clinical Trial |
title_fullStr | The Benefits of Neuromuscular Electrical Stimulation in the Muscular
and Functional Capacity of Patients With Liver Cirrhosis: Protocol for a
Randomized Clinical Trial |
title_full_unstemmed | The Benefits of Neuromuscular Electrical Stimulation in the Muscular
and Functional Capacity of Patients With Liver Cirrhosis: Protocol for a
Randomized Clinical Trial |
title_short | The Benefits of Neuromuscular Electrical Stimulation in the Muscular
and Functional Capacity of Patients With Liver Cirrhosis: Protocol for a
Randomized Clinical Trial |
title_sort | benefits of neuromuscular electrical stimulation in the muscular
and functional capacity of patients with liver cirrhosis: protocol for a
randomized clinical trial |
topic | Study Protocol |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6256309/ https://www.ncbi.nlm.nih.gov/pubmed/30505152 http://dx.doi.org/10.1177/1179552218811834 |
work_keys_str_mv | AT demellocarolinaluana thebenefitsofneuromuscularelectricalstimulationinthemuscularandfunctionalcapacityofpatientswithlivercirrhosisprotocolforarandomizedclinicaltrial AT daconceicaothaismartinsalbanaz thebenefitsofneuromuscularelectricalstimulationinthemuscularandfunctionalcapacityofpatientswithlivercirrhosisprotocolforarandomizedclinicaltrial AT dalponttarcila thebenefitsofneuromuscularelectricalstimulationinthemuscularandfunctionalcapacityofpatientswithlivercirrhosisprotocolforarandomizedclinicaltrial AT peruzzolocatherinecorrea thebenefitsofneuromuscularelectricalstimulationinthemuscularandfunctionalcapacityofpatientswithlivercirrhosisprotocolforarandomizedclinicaltrial AT luciomariananunes thebenefitsofneuromuscularelectricalstimulationinthemuscularandfunctionalcapacityofpatientswithlivercirrhosisprotocolforarandomizedclinicaltrial AT paulinelaine thebenefitsofneuromuscularelectricalstimulationinthemuscularandfunctionalcapacityofpatientswithlivercirrhosisprotocolforarandomizedclinicaltrial AT demellocarolinaluana benefitsofneuromuscularelectricalstimulationinthemuscularandfunctionalcapacityofpatientswithlivercirrhosisprotocolforarandomizedclinicaltrial AT daconceicaothaismartinsalbanaz benefitsofneuromuscularelectricalstimulationinthemuscularandfunctionalcapacityofpatientswithlivercirrhosisprotocolforarandomizedclinicaltrial AT dalponttarcila benefitsofneuromuscularelectricalstimulationinthemuscularandfunctionalcapacityofpatientswithlivercirrhosisprotocolforarandomizedclinicaltrial AT peruzzolocatherinecorrea benefitsofneuromuscularelectricalstimulationinthemuscularandfunctionalcapacityofpatientswithlivercirrhosisprotocolforarandomizedclinicaltrial AT luciomariananunes benefitsofneuromuscularelectricalstimulationinthemuscularandfunctionalcapacityofpatientswithlivercirrhosisprotocolforarandomizedclinicaltrial AT paulinelaine benefitsofneuromuscularelectricalstimulationinthemuscularandfunctionalcapacityofpatientswithlivercirrhosisprotocolforarandomizedclinicaltrial |