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MicroRNA-34a inhibits metastasis in liver cancer cells

MicroRNAs (miRNA/miRs) have the ability to target specific mRNAs, resulting in degradation of mRNA or inhibition of translation. Notably, miR-34a is able to regulate cell cycle and tumorigenicity. The level of miR-34a expression is usually low in tumors, and previous studies have indicated miR-34a t...

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Detalles Bibliográficos
Autores principales: Wei, Wei, Tang, Huihuan, Tang, Ling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6256319/
https://www.ncbi.nlm.nih.gov/pubmed/30546428
http://dx.doi.org/10.3892/ol.2018.9555
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author Wei, Wei
Tang, Huihuan
Tang, Ling
author_facet Wei, Wei
Tang, Huihuan
Tang, Ling
author_sort Wei, Wei
collection PubMed
description MicroRNAs (miRNA/miRs) have the ability to target specific mRNAs, resulting in degradation of mRNA or inhibition of translation. Notably, miR-34a is able to regulate cell cycle and tumorigenicity. The level of miR-34a expression is usually low in tumors, and previous studies have indicated miR-34a to be an important tumor suppressor. In order to elucidate the association between miR-34a and metastasis, stable cell lines were established and transfected with miR-34a. Cell invasion assay was subsequently performed. The present study demonstrated that cell invasion was inhibited in cells that were transfected with miR-34a compared with the control group (P<0.05). Therefore, miR-34a was able to inhibit metastasis in liver cancer cells.
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spelling pubmed-62563192018-12-13 MicroRNA-34a inhibits metastasis in liver cancer cells Wei, Wei Tang, Huihuan Tang, Ling Oncol Lett Articles MicroRNAs (miRNA/miRs) have the ability to target specific mRNAs, resulting in degradation of mRNA or inhibition of translation. Notably, miR-34a is able to regulate cell cycle and tumorigenicity. The level of miR-34a expression is usually low in tumors, and previous studies have indicated miR-34a to be an important tumor suppressor. In order to elucidate the association between miR-34a and metastasis, stable cell lines were established and transfected with miR-34a. Cell invasion assay was subsequently performed. The present study demonstrated that cell invasion was inhibited in cells that were transfected with miR-34a compared with the control group (P<0.05). Therefore, miR-34a was able to inhibit metastasis in liver cancer cells. D.A. Spandidos 2018-12 2018-10-09 /pmc/articles/PMC6256319/ /pubmed/30546428 http://dx.doi.org/10.3892/ol.2018.9555 Text en Copyright: © Wei et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Articles
Wei, Wei
Tang, Huihuan
Tang, Ling
MicroRNA-34a inhibits metastasis in liver cancer cells
title MicroRNA-34a inhibits metastasis in liver cancer cells
title_full MicroRNA-34a inhibits metastasis in liver cancer cells
title_fullStr MicroRNA-34a inhibits metastasis in liver cancer cells
title_full_unstemmed MicroRNA-34a inhibits metastasis in liver cancer cells
title_short MicroRNA-34a inhibits metastasis in liver cancer cells
title_sort microrna-34a inhibits metastasis in liver cancer cells
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6256319/
https://www.ncbi.nlm.nih.gov/pubmed/30546428
http://dx.doi.org/10.3892/ol.2018.9555
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AT tanghuihuan microrna34ainhibitsmetastasisinlivercancercells
AT tangling microrna34ainhibitsmetastasisinlivercancercells