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Chitosan-based nanoparticles with damnacanthal suppress CRM1 expression

Cancer is one of the leading causes of mortality worldwide. Phytochemicals may be promising anticancer agents given their various chemical structures and diverse biological activities. Damnacanthal (DAM) is a major bioactive component of Noni, which has been investigated previously as a cancer-preve...

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Autores principales: Chaichanasak, Nadda, Rojanapanthu, Pleumchitt, Yoon, Yongdae, Gritsanapan, Wandee, Chirachanchai, Suwabun, Sathirakul, Korbtham, Nualsanit, Thararat, Seong, Je Kyung, Baek, Seung Joon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6256335/
https://www.ncbi.nlm.nih.gov/pubmed/30546436
http://dx.doi.org/10.3892/ol.2018.9507
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author Chaichanasak, Nadda
Rojanapanthu, Pleumchitt
Yoon, Yongdae
Gritsanapan, Wandee
Chirachanchai, Suwabun
Sathirakul, Korbtham
Nualsanit, Thararat
Seong, Je Kyung
Baek, Seung Joon
author_facet Chaichanasak, Nadda
Rojanapanthu, Pleumchitt
Yoon, Yongdae
Gritsanapan, Wandee
Chirachanchai, Suwabun
Sathirakul, Korbtham
Nualsanit, Thararat
Seong, Je Kyung
Baek, Seung Joon
author_sort Chaichanasak, Nadda
collection PubMed
description Cancer is one of the leading causes of mortality worldwide. Phytochemicals may be promising anticancer agents given their various chemical structures and diverse biological activities. Damnacanthal (DAM) is a major bioactive component of Noni, which has been investigated previously as a cancer-preventive or chemotherapeutic agent. DAM has also been reported to exhibit anti-proliferative activity in several cancer types. In the present study, it was identified that DAM downregulates chromosome maintenance protein 1 (CRM1) expression in human cancer cells. The application of chitosan-based nanoparticles (NPs) with DAM also induced CRM1 downregulation, which suggests that chitosan-based NPs may be effective vehicles for delivery of phytochemicals such as DAM. It was also identified that DAM increased the levels of the tumor suppressor non-steroidal anti-inflammatory drugs-activated gene 1 in the nucleus, thereby leading to enhanced anticancer effects. The results of the present study indicate that DAM and its nanoformulation may be a candidate anticancer drug.
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spelling pubmed-62563352018-12-13 Chitosan-based nanoparticles with damnacanthal suppress CRM1 expression Chaichanasak, Nadda Rojanapanthu, Pleumchitt Yoon, Yongdae Gritsanapan, Wandee Chirachanchai, Suwabun Sathirakul, Korbtham Nualsanit, Thararat Seong, Je Kyung Baek, Seung Joon Oncol Lett Articles Cancer is one of the leading causes of mortality worldwide. Phytochemicals may be promising anticancer agents given their various chemical structures and diverse biological activities. Damnacanthal (DAM) is a major bioactive component of Noni, which has been investigated previously as a cancer-preventive or chemotherapeutic agent. DAM has also been reported to exhibit anti-proliferative activity in several cancer types. In the present study, it was identified that DAM downregulates chromosome maintenance protein 1 (CRM1) expression in human cancer cells. The application of chitosan-based nanoparticles (NPs) with DAM also induced CRM1 downregulation, which suggests that chitosan-based NPs may be effective vehicles for delivery of phytochemicals such as DAM. It was also identified that DAM increased the levels of the tumor suppressor non-steroidal anti-inflammatory drugs-activated gene 1 in the nucleus, thereby leading to enhanced anticancer effects. The results of the present study indicate that DAM and its nanoformulation may be a candidate anticancer drug. D.A. Spandidos 2018-12 2018-09-26 /pmc/articles/PMC6256335/ /pubmed/30546436 http://dx.doi.org/10.3892/ol.2018.9507 Text en Copyright: © Chaichanasak et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Articles
Chaichanasak, Nadda
Rojanapanthu, Pleumchitt
Yoon, Yongdae
Gritsanapan, Wandee
Chirachanchai, Suwabun
Sathirakul, Korbtham
Nualsanit, Thararat
Seong, Je Kyung
Baek, Seung Joon
Chitosan-based nanoparticles with damnacanthal suppress CRM1 expression
title Chitosan-based nanoparticles with damnacanthal suppress CRM1 expression
title_full Chitosan-based nanoparticles with damnacanthal suppress CRM1 expression
title_fullStr Chitosan-based nanoparticles with damnacanthal suppress CRM1 expression
title_full_unstemmed Chitosan-based nanoparticles with damnacanthal suppress CRM1 expression
title_short Chitosan-based nanoparticles with damnacanthal suppress CRM1 expression
title_sort chitosan-based nanoparticles with damnacanthal suppress crm1 expression
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6256335/
https://www.ncbi.nlm.nih.gov/pubmed/30546436
http://dx.doi.org/10.3892/ol.2018.9507
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