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Capnocytophaga canimorsus Capsular Serovar and Disease Severity, Helsinki Hospital District, Finland, 2000–2017

We assembled a collection of 73 Capnocytophaga canimorsus isolates obtained from blood cultures taken from patients treated at Helsinki University Hospital (Helsinki, Finland) during 2000–2017. We serotyped these isolates by PCR and Western blot and attempted to correlate pathogen serovar with patie...

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Autores principales: Hess, Estelle, Renzi, Francesco, Karhunen, Panu, Dol, Mélanie, Lefèvre, Adrien, Antikainen, Jenni, Carlier, Elodie, Hästbacka, Johanna, Cornelis, Guy R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6256374/
https://www.ncbi.nlm.nih.gov/pubmed/30457520
http://dx.doi.org/10.3201/eid2412.172060
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author Hess, Estelle
Renzi, Francesco
Karhunen, Panu
Dol, Mélanie
Lefèvre, Adrien
Antikainen, Jenni
Carlier, Elodie
Hästbacka, Johanna
Cornelis, Guy R.
author_facet Hess, Estelle
Renzi, Francesco
Karhunen, Panu
Dol, Mélanie
Lefèvre, Adrien
Antikainen, Jenni
Carlier, Elodie
Hästbacka, Johanna
Cornelis, Guy R.
author_sort Hess, Estelle
collection PubMed
description We assembled a collection of 73 Capnocytophaga canimorsus isolates obtained from blood cultures taken from patients treated at Helsinki University Hospital (Helsinki, Finland) during 2000–2017. We serotyped these isolates by PCR and Western blot and attempted to correlate pathogen serovar with patient characteristics. Our analyses showed, in agreement with previous research, that 3 C. canimorsus serovars (A–C) caused most (91.8%) human infections, despite constituting only 7.6% of isolates found in dogs. The 3 fatalities that occurred in our cohort were equally represented by these serovars. We found 2 untypeable isolates, which we designated serovars J and K. We did not detect an association between serovar and disease severity, immune status, alcohol abuse, or smoking status, but dog bites occurred more frequently among patients infected with non-A–C serovars. Future research is needed to confirm serovar virulence and develop strategies to reduce risk for these infections in humans.
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spelling pubmed-62563742018-12-05 Capnocytophaga canimorsus Capsular Serovar and Disease Severity, Helsinki Hospital District, Finland, 2000–2017 Hess, Estelle Renzi, Francesco Karhunen, Panu Dol, Mélanie Lefèvre, Adrien Antikainen, Jenni Carlier, Elodie Hästbacka, Johanna Cornelis, Guy R. Emerg Infect Dis Research We assembled a collection of 73 Capnocytophaga canimorsus isolates obtained from blood cultures taken from patients treated at Helsinki University Hospital (Helsinki, Finland) during 2000–2017. We serotyped these isolates by PCR and Western blot and attempted to correlate pathogen serovar with patient characteristics. Our analyses showed, in agreement with previous research, that 3 C. canimorsus serovars (A–C) caused most (91.8%) human infections, despite constituting only 7.6% of isolates found in dogs. The 3 fatalities that occurred in our cohort were equally represented by these serovars. We found 2 untypeable isolates, which we designated serovars J and K. We did not detect an association between serovar and disease severity, immune status, alcohol abuse, or smoking status, but dog bites occurred more frequently among patients infected with non-A–C serovars. Future research is needed to confirm serovar virulence and develop strategies to reduce risk for these infections in humans. Centers for Disease Control and Prevention 2018-12 /pmc/articles/PMC6256374/ /pubmed/30457520 http://dx.doi.org/10.3201/eid2412.172060 Text en https://creativecommons.org/licenses/by/4.0/This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited.
spellingShingle Research
Hess, Estelle
Renzi, Francesco
Karhunen, Panu
Dol, Mélanie
Lefèvre, Adrien
Antikainen, Jenni
Carlier, Elodie
Hästbacka, Johanna
Cornelis, Guy R.
Capnocytophaga canimorsus Capsular Serovar and Disease Severity, Helsinki Hospital District, Finland, 2000–2017
title Capnocytophaga canimorsus Capsular Serovar and Disease Severity, Helsinki Hospital District, Finland, 2000–2017
title_full Capnocytophaga canimorsus Capsular Serovar and Disease Severity, Helsinki Hospital District, Finland, 2000–2017
title_fullStr Capnocytophaga canimorsus Capsular Serovar and Disease Severity, Helsinki Hospital District, Finland, 2000–2017
title_full_unstemmed Capnocytophaga canimorsus Capsular Serovar and Disease Severity, Helsinki Hospital District, Finland, 2000–2017
title_short Capnocytophaga canimorsus Capsular Serovar and Disease Severity, Helsinki Hospital District, Finland, 2000–2017
title_sort capnocytophaga canimorsus capsular serovar and disease severity, helsinki hospital district, finland, 2000–2017
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6256374/
https://www.ncbi.nlm.nih.gov/pubmed/30457520
http://dx.doi.org/10.3201/eid2412.172060
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