Competitive Fitness of Essential Gene Knockdowns Reveals a Broad-Spectrum Antibacterial Inhibitor of the Cell Division Protein FtsZ

To streamline the elucidation of antibacterial compounds’ mechanism of action, comprehensive high-throughput assays interrogating multiple putative targets are necessary. However, current chemogenomic approaches for antibiotic target identification have not fully utilized the multiplexing potential...

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Detalles Bibliográficos
Autores principales: Hogan, Andrew M., Scoffone, Viola C., Makarov, Vadim, Gislason, April S., Tesfu, Haben, Stietz, Maria S., Brassinga, Ann Karen C., Domaratzki, Michael, Li, Xuan, Azzalin, Alberto, Biggiogera, Marco, Riabova, Olga, Monakhova, Natalia, Chiarelli, Laurent R., Riccardi, Giovanna, Buroni, Silvia, Cardona, Silvia T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2018
Materias:
Mechanisms of Action: Physiological Effects
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6256756/
https://www.ncbi.nlm.nih.gov/pubmed/30297366
http://dx.doi.org/10.1128/AAC.01231-18

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