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Gametocytes from K13 Propeller Mutant Plasmodium falciparum Clinical Isolates Demonstrate Reduced Susceptibility to Dihydroartemisinin in the Male Gamete Exflagellation Inhibition Assay

Mutations in the kelch propeller domain (K13 propeller) of Plasmodium falciparum parasites from Southeast Asia are associated with reduced susceptibility to artemisinin. We exposed in vitro-cultured stage V gametocytes from Cambodian K13 propeller mutant parasites to dihydroartemisinin and evaluated...

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Detalles Bibliográficos
Autores principales:	Lozano, Sonia, Gamallo, Pablo, González-Cortés, Carolina, Presa Matilla, Jesús-Luís, Fairhurst, Rick M., Herreros, Esperanza, Amaratunga, Chanaki, Rodrigues, Janneth
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2018
Materias:	Susceptibility
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6256798/ https://www.ncbi.nlm.nih.gov/pubmed/30224530 http://dx.doi.org/10.1128/AAC.01426-18

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