Dynamic changes and diagnostic and prognostic significance of serum PCT, hs-CRP and s-100 protein in central nervous system infection

The aim of the study was to analyze the dynamic changes and diagnostic and prognostic significance of serum procalcitonin (PCT), high-sensitivity C-reactive protein (hs-CRP) and s-100 protein in central nervous system infection. A total of 110 patients diagnosed with central nervous system infection in Department of Neurology in the People's Hospital of Rizhao from January 2014 to January 2016 were selected and retrospectively analyzed; they were divided into the bacterium (n=70) and virus (n=40) groups. Another 45 normal subjects were selected as the control group. PCT, hs-CRP and s-100 protein values in serum and cerebrospinal fluid were measured. The serum PCT, hs-CRP and s-100 protein levels in the bacterium group were significantly higher than those in the virus and control groups (p<0.05). The serum PCT, hs-CRP and s-100 protein levels in the bacterium and virus groups after treatment were obviously decreased compared with those before treatment (p<0.05). PCT, hs-CRP and s-100 protein levels in serum and cerebrospinal fluid in the bacterium and virus groups had no statistically significant differences after treatment (p>0.05). PCT, hs-CRP and s-100 protein levels in deaths in bacterium group were significantly higher than those in survivors (p<0.05). The serum PCT, hs-CRP and s-100 protein levels, can serve as important indexes for the diagnosis of central nervous system infection and their dynamic changes can be used to monitor the changes in disease condition, severity of bacterial infection and prognosis, providing help for the clinical treatment thereof.