Synthesis and Characterization of Long-Chain Tartaric Acid Diamides as Novel Ceramide-Like Compounds

Ceramides play a crucial role in the barrier function of the skin as well as in transmembrane signaling. In this study long aliphatic chain tartaric acid diamides able to replace ceramides in an in vitro model of the stratum corneum lipid matrix due to their similar physico-chemical properties were...

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Detalles Bibliográficos
Autores principales: Sinkó, Bálint, Pálfi, Melinda, Béni, Szabolcs, Kökösi, József, Takács-Novák, Krisztina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6256927/
https://www.ncbi.nlm.nih.gov/pubmed/20335949
http://dx.doi.org/10.3390/molecules15020824
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author Sinkó, Bálint
Pálfi, Melinda
Béni, Szabolcs
Kökösi, József
Takács-Novák, Krisztina
author_facet Sinkó, Bálint
Pálfi, Melinda
Béni, Szabolcs
Kökösi, József
Takács-Novák, Krisztina
author_sort Sinkó, Bálint
collection PubMed
description Ceramides play a crucial role in the barrier function of the skin as well as in transmembrane signaling. In this study long aliphatic chain tartaric acid diamides able to replace ceramides in an in vitro model of the stratum corneum lipid matrix due to their similar physico-chemical properties were synthesized from diacetoxysuccinic anhydride in four steps. Their pro-apoptotic effect on fibroblast cells was also investigated.
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spelling pubmed-62569272018-12-03 Synthesis and Characterization of Long-Chain Tartaric Acid Diamides as Novel Ceramide-Like Compounds Sinkó, Bálint Pálfi, Melinda Béni, Szabolcs Kökösi, József Takács-Novák, Krisztina Molecules Article Ceramides play a crucial role in the barrier function of the skin as well as in transmembrane signaling. In this study long aliphatic chain tartaric acid diamides able to replace ceramides in an in vitro model of the stratum corneum lipid matrix due to their similar physico-chemical properties were synthesized from diacetoxysuccinic anhydride in four steps. Their pro-apoptotic effect on fibroblast cells was also investigated. Molecular Diversity Preservation International 2010-02-05 /pmc/articles/PMC6256927/ /pubmed/20335949 http://dx.doi.org/10.3390/molecules15020824 Text en © 2010 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland. This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Sinkó, Bálint
Pálfi, Melinda
Béni, Szabolcs
Kökösi, József
Takács-Novák, Krisztina
Synthesis and Characterization of Long-Chain Tartaric Acid Diamides as Novel Ceramide-Like Compounds
title Synthesis and Characterization of Long-Chain Tartaric Acid Diamides as Novel Ceramide-Like Compounds
title_full Synthesis and Characterization of Long-Chain Tartaric Acid Diamides as Novel Ceramide-Like Compounds
title_fullStr Synthesis and Characterization of Long-Chain Tartaric Acid Diamides as Novel Ceramide-Like Compounds
title_full_unstemmed Synthesis and Characterization of Long-Chain Tartaric Acid Diamides as Novel Ceramide-Like Compounds
title_short Synthesis and Characterization of Long-Chain Tartaric Acid Diamides as Novel Ceramide-Like Compounds
title_sort synthesis and characterization of long-chain tartaric acid diamides as novel ceramide-like compounds
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6256927/
https://www.ncbi.nlm.nih.gov/pubmed/20335949
http://dx.doi.org/10.3390/molecules15020824
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