Antileishmanial, Antimicrobial and Antifungal Activities of Some New Aryl Azomethines

A series of eighteen azomethines has been synthesized by the reaction of appropriate primary aromatic amines with aryl and/or heteroaryl carboxaldehydes. The synthesized azomethines have been evaluated for their in vitro antileishmanial, antibacterial and antifungal activities. The results revealed...

Descripción completa

Detalles Bibliográficos
Autores principales: Al-Kahraman, Yasser M.S.A., Madkour, Hassan. M.F., Ali, Dildar, Yasinzai, Masoom
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6256931/
https://www.ncbi.nlm.nih.gov/pubmed/20335936
http://dx.doi.org/10.3390/molecules15020660
_version_ 1783374243905404928
author Al-Kahraman, Yasser M.S.A.
Madkour, Hassan. M.F.
Ali, Dildar
Yasinzai, Masoom
author_facet Al-Kahraman, Yasser M.S.A.
Madkour, Hassan. M.F.
Ali, Dildar
Yasinzai, Masoom
author_sort Al-Kahraman, Yasser M.S.A.
collection PubMed
description A series of eighteen azomethines has been synthesized by the reaction of appropriate primary aromatic amines with aryl and/or heteroaryl carboxaldehydes. The synthesized azomethines have been evaluated for their in vitro antileishmanial, antibacterial and antifungal activities. The results revealed some antifungal activity of most of the synthesized compounds, whereas the antileishmaniasis activity results highlighted that all synthesized azomethines inhibited parasite growth and most of them showed highly potent action towards Leishmania major promastigotes. No remarkable bactericidal activities were observed.
format Online
Article
Text
id pubmed-6256931
institution National Center for Biotechnology Information
language English
publishDate 2010
publisher Molecular Diversity Preservation International
record_format MEDLINE/PubMed
spelling pubmed-62569312018-12-03 Antileishmanial, Antimicrobial and Antifungal Activities of Some New Aryl Azomethines Al-Kahraman, Yasser M.S.A. Madkour, Hassan. M.F. Ali, Dildar Yasinzai, Masoom Molecules Article A series of eighteen azomethines has been synthesized by the reaction of appropriate primary aromatic amines with aryl and/or heteroaryl carboxaldehydes. The synthesized azomethines have been evaluated for their in vitro antileishmanial, antibacterial and antifungal activities. The results revealed some antifungal activity of most of the synthesized compounds, whereas the antileishmaniasis activity results highlighted that all synthesized azomethines inhibited parasite growth and most of them showed highly potent action towards Leishmania major promastigotes. No remarkable bactericidal activities were observed. Molecular Diversity Preservation International 2010-01-28 /pmc/articles/PMC6256931/ /pubmed/20335936 http://dx.doi.org/10.3390/molecules15020660 Text en © 2010 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Al-Kahraman, Yasser M.S.A.
Madkour, Hassan. M.F.
Ali, Dildar
Yasinzai, Masoom
Antileishmanial, Antimicrobial and Antifungal Activities of Some New Aryl Azomethines
title Antileishmanial, Antimicrobial and Antifungal Activities of Some New Aryl Azomethines
title_full Antileishmanial, Antimicrobial and Antifungal Activities of Some New Aryl Azomethines
title_fullStr Antileishmanial, Antimicrobial and Antifungal Activities of Some New Aryl Azomethines
title_full_unstemmed Antileishmanial, Antimicrobial and Antifungal Activities of Some New Aryl Azomethines
title_short Antileishmanial, Antimicrobial and Antifungal Activities of Some New Aryl Azomethines
title_sort antileishmanial, antimicrobial and antifungal activities of some new aryl azomethines
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6256931/
https://www.ncbi.nlm.nih.gov/pubmed/20335936
http://dx.doi.org/10.3390/molecules15020660
work_keys_str_mv AT alkahramanyassermsa antileishmanialantimicrobialandantifungalactivitiesofsomenewarylazomethines
AT madkourhassanmf antileishmanialantimicrobialandantifungalactivitiesofsomenewarylazomethines
AT alidildar antileishmanialantimicrobialandantifungalactivitiesofsomenewarylazomethines
AT yasinzaimasoom antileishmanialantimicrobialandantifungalactivitiesofsomenewarylazomethines

Ejemplares similares