Synthesis and in Vitro Cytotoxic Activity of Compounds with Pro-Apoptotic Potential

In our search for new anticancer therapies, some compounds synthesized in our lab were selected and their potential cytotoxic activity was evaluated in vitro against two cancer cells lines including a solid tumor (UACC-62, melanoma) and a human lymphoma (JURKAT). Compounds showing cytotoxic activity...

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Autores principales: Soares, Giselle Apicela, de Oliveira, Renata Barbosa, de Andrade, Saulo Fernandes, Alves, Ricardo José, Zani, Carlos Leomar, de Souza-Fagundes, Elaine Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6256932/
https://www.ncbi.nlm.nih.gov/pubmed/20110868
http://dx.doi.org/10.3390/molecules15010012
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author Soares, Giselle Apicela
de Oliveira, Renata Barbosa
de Andrade, Saulo Fernandes
Alves, Ricardo José
Zani, Carlos Leomar
de Souza-Fagundes, Elaine Maria
author_facet Soares, Giselle Apicela
de Oliveira, Renata Barbosa
de Andrade, Saulo Fernandes
Alves, Ricardo José
Zani, Carlos Leomar
de Souza-Fagundes, Elaine Maria
author_sort Soares, Giselle Apicela
collection PubMed
description In our search for new anticancer therapies, some compounds synthesized in our lab were selected and their potential cytotoxic activity was evaluated in vitro against two cancer cells lines including a solid tumor (UACC-62, melanoma) and a human lymphoma (JURKAT). Compounds showing cytotoxic activity were subjected to an apoptosis assay. Two compounds showed promising results.
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spelling pubmed-62569322018-12-03 Synthesis and in Vitro Cytotoxic Activity of Compounds with Pro-Apoptotic Potential Soares, Giselle Apicela de Oliveira, Renata Barbosa de Andrade, Saulo Fernandes Alves, Ricardo José Zani, Carlos Leomar de Souza-Fagundes, Elaine Maria Molecules Article In our search for new anticancer therapies, some compounds synthesized in our lab were selected and their potential cytotoxic activity was evaluated in vitro against two cancer cells lines including a solid tumor (UACC-62, melanoma) and a human lymphoma (JURKAT). Compounds showing cytotoxic activity were subjected to an apoptosis assay. Two compounds showed promising results. Molecular Diversity Preservation International 2009-12-24 /pmc/articles/PMC6256932/ /pubmed/20110868 http://dx.doi.org/10.3390/molecules15010012 Text en © 2010 by the authors; http://creativecommons.org/licenses/by/3.0/ licensee Molecular Diversity Preservation International, Basel, Switzerland. This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Soares, Giselle Apicela
de Oliveira, Renata Barbosa
de Andrade, Saulo Fernandes
Alves, Ricardo José
Zani, Carlos Leomar
de Souza-Fagundes, Elaine Maria
Synthesis and in Vitro Cytotoxic Activity of Compounds with Pro-Apoptotic Potential
title Synthesis and in Vitro Cytotoxic Activity of Compounds with Pro-Apoptotic Potential
title_full Synthesis and in Vitro Cytotoxic Activity of Compounds with Pro-Apoptotic Potential
title_fullStr Synthesis and in Vitro Cytotoxic Activity of Compounds with Pro-Apoptotic Potential
title_full_unstemmed Synthesis and in Vitro Cytotoxic Activity of Compounds with Pro-Apoptotic Potential
title_short Synthesis and in Vitro Cytotoxic Activity of Compounds with Pro-Apoptotic Potential
title_sort synthesis and in vitro cytotoxic activity of compounds with pro-apoptotic potential
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6256932/
https://www.ncbi.nlm.nih.gov/pubmed/20110868
http://dx.doi.org/10.3390/molecules15010012
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