Investigating the Activity Spectrum for Ring-Substituted 8-Hydroxyquinolines

In this study, a series of fourteen ring-substituted 8-hydroxyquinoline derivatives were prepared. The synthesis procedures are presented. The compounds were analyzed using RP-HPLC to determine lipophilicity. They were tested for their activity related to inhibition of photosynthetic electron transp...

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Autores principales: Musiol, Robert, Jampilek, Josef, Nycz, Jacek E., Pesko, Matus, Carroll, James, Kralova, Katarina, Vejsova, Marcela, O'Mahony, Jim, Coffey, Aidan, Mrozek, Anna, Polanski, Jaroslaw
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6256987/
https://www.ncbi.nlm.nih.gov/pubmed/20110891
http://dx.doi.org/10.3390/molecules15010288
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author Musiol, Robert
Jampilek, Josef
Nycz, Jacek E.
Pesko, Matus
Carroll, James
Kralova, Katarina
Vejsova, Marcela
O'Mahony, Jim
Coffey, Aidan
Mrozek, Anna
Polanski, Jaroslaw
author_facet Musiol, Robert
Jampilek, Josef
Nycz, Jacek E.
Pesko, Matus
Carroll, James
Kralova, Katarina
Vejsova, Marcela
O'Mahony, Jim
Coffey, Aidan
Mrozek, Anna
Polanski, Jaroslaw
author_sort Musiol, Robert
collection PubMed
description In this study, a series of fourteen ring-substituted 8-hydroxyquinoline derivatives were prepared. The synthesis procedures are presented. The compounds were analyzed using RP-HPLC to determine lipophilicity. They were tested for their activity related to inhibition of photosynthetic electron transport (PET) in spinach (Spinacia oleracea L.) chloroplasts. Primary in vitro screening of the synthesized compounds was also performed against four mycobacterial strains and against eight fungal strains. Several compounds showed biological activity comparable with or higher than the standards isoniazid or fluconazole. For all the compounds, the relationships between the lipophilicity and the chemical structure of the studied compounds are discussed.
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spelling pubmed-62569872018-12-03 Investigating the Activity Spectrum for Ring-Substituted 8-Hydroxyquinolines Musiol, Robert Jampilek, Josef Nycz, Jacek E. Pesko, Matus Carroll, James Kralova, Katarina Vejsova, Marcela O'Mahony, Jim Coffey, Aidan Mrozek, Anna Polanski, Jaroslaw Molecules Article In this study, a series of fourteen ring-substituted 8-hydroxyquinoline derivatives were prepared. The synthesis procedures are presented. The compounds were analyzed using RP-HPLC to determine lipophilicity. They were tested for their activity related to inhibition of photosynthetic electron transport (PET) in spinach (Spinacia oleracea L.) chloroplasts. Primary in vitro screening of the synthesized compounds was also performed against four mycobacterial strains and against eight fungal strains. Several compounds showed biological activity comparable with or higher than the standards isoniazid or fluconazole. For all the compounds, the relationships between the lipophilicity and the chemical structure of the studied compounds are discussed. Molecular Diversity Preservation International 2010-01-12 /pmc/articles/PMC6256987/ /pubmed/20110891 http://dx.doi.org/10.3390/molecules15010288 Text en © 2010 by the authors; http://creativecommons.org/licenses/by/3.0/ licensee Molecular Diversity Preservation International, Basel, Switzerland. This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Musiol, Robert
Jampilek, Josef
Nycz, Jacek E.
Pesko, Matus
Carroll, James
Kralova, Katarina
Vejsova, Marcela
O'Mahony, Jim
Coffey, Aidan
Mrozek, Anna
Polanski, Jaroslaw
Investigating the Activity Spectrum for Ring-Substituted 8-Hydroxyquinolines
title Investigating the Activity Spectrum for Ring-Substituted 8-Hydroxyquinolines
title_full Investigating the Activity Spectrum for Ring-Substituted 8-Hydroxyquinolines
title_fullStr Investigating the Activity Spectrum for Ring-Substituted 8-Hydroxyquinolines
title_full_unstemmed Investigating the Activity Spectrum for Ring-Substituted 8-Hydroxyquinolines
title_short Investigating the Activity Spectrum for Ring-Substituted 8-Hydroxyquinolines
title_sort investigating the activity spectrum for ring-substituted 8-hydroxyquinolines
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6256987/
https://www.ncbi.nlm.nih.gov/pubmed/20110891
http://dx.doi.org/10.3390/molecules15010288
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