Microwave-Assisted and Efficient Solvent-Free Knoevenagel Condensation. A Sustainable Protocol Using Porous Calcium Hydroxyapatite as Catalyst

A sustainable Knoevenagel condensation of a series of aldehydes with malononitrile and ethyl cyanoacetate is described. The process is based on the combination of microwave activation and hydroxyapatite catalysis under solvent-free conditions. Products are obtained in and high yields after short rea...

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Autores principales: Mallouk, Siham, Bougrin, Khalid, Laghzizil, Abdelaziz, Benhida, Rachid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6257047/
https://www.ncbi.nlm.nih.gov/pubmed/20335948
http://dx.doi.org/10.3390/molecules15020813
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author Mallouk, Siham
Bougrin, Khalid
Laghzizil, Abdelaziz
Benhida, Rachid
author_facet Mallouk, Siham
Bougrin, Khalid
Laghzizil, Abdelaziz
Benhida, Rachid
author_sort Mallouk, Siham
collection PubMed
description A sustainable Knoevenagel condensation of a series of aldehydes with malononitrile and ethyl cyanoacetate is described. The process is based on the combination of microwave activation and hydroxyapatite catalysis under solvent-free conditions. Products are obtained in and high yields after short reaction times. The effects of the specific surface of porous calcium hydroxyapatite and microwave activation are discussed.
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spelling pubmed-62570472018-12-03 Microwave-Assisted and Efficient Solvent-Free Knoevenagel Condensation. A Sustainable Protocol Using Porous Calcium Hydroxyapatite as Catalyst Mallouk, Siham Bougrin, Khalid Laghzizil, Abdelaziz Benhida, Rachid Molecules Article A sustainable Knoevenagel condensation of a series of aldehydes with malononitrile and ethyl cyanoacetate is described. The process is based on the combination of microwave activation and hydroxyapatite catalysis under solvent-free conditions. Products are obtained in and high yields after short reaction times. The effects of the specific surface of porous calcium hydroxyapatite and microwave activation are discussed. Molecular Diversity Preservation International 2010-02-04 /pmc/articles/PMC6257047/ /pubmed/20335948 http://dx.doi.org/10.3390/molecules15020813 Text en © 2010 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland. This article is an open-access article distributed under the terms and conditions of the CreativeCommons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Mallouk, Siham
Bougrin, Khalid
Laghzizil, Abdelaziz
Benhida, Rachid
Microwave-Assisted and Efficient Solvent-Free Knoevenagel Condensation. A Sustainable Protocol Using Porous Calcium Hydroxyapatite as Catalyst
title Microwave-Assisted and Efficient Solvent-Free Knoevenagel Condensation. A Sustainable Protocol Using Porous Calcium Hydroxyapatite as Catalyst
title_full Microwave-Assisted and Efficient Solvent-Free Knoevenagel Condensation. A Sustainable Protocol Using Porous Calcium Hydroxyapatite as Catalyst
title_fullStr Microwave-Assisted and Efficient Solvent-Free Knoevenagel Condensation. A Sustainable Protocol Using Porous Calcium Hydroxyapatite as Catalyst
title_full_unstemmed Microwave-Assisted and Efficient Solvent-Free Knoevenagel Condensation. A Sustainable Protocol Using Porous Calcium Hydroxyapatite as Catalyst
title_short Microwave-Assisted and Efficient Solvent-Free Knoevenagel Condensation. A Sustainable Protocol Using Porous Calcium Hydroxyapatite as Catalyst
title_sort microwave-assisted and efficient solvent-free knoevenagel condensation. a sustainable protocol using porous calcium hydroxyapatite as catalyst
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6257047/
https://www.ncbi.nlm.nih.gov/pubmed/20335948
http://dx.doi.org/10.3390/molecules15020813
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