Synthesis of New Imidazolidin-2,4-dione and 2-Thioxo-imidazolidin-4-ones via C-Phenylglycine Derivatives

Hydantoins and their derivatives constitute a group of pharmaceutical compounds with anticonvulsant and antiarrhythmic properties, and are also used against diabetes. N-3 and C-5 substituted imidazolidines are examples of such products. As such, we have developed a synthesis of 2,4-dione and 2-thiox...

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Detalles Bibliográficos
Autores principales: de Sousa Luis, José Alixandre, Barbosa Filho, José Maria, Freitas Lira, Bruno, Almeida Medeiros, Isac, Soares Lima de Morais, Liana Clébia, dos Santos, Alexsandro Fernandes, Soares de Oliveira, Cledualdo, de Athayde-Filho, Petrônio Filgueiras
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6257050/
https://www.ncbi.nlm.nih.gov/pubmed/20110877
http://dx.doi.org/10.3390/molecules15010128
Descripción
Sumario:Hydantoins and their derivatives constitute a group of pharmaceutical compounds with anticonvulsant and antiarrhythmic properties, and are also used against diabetes. N-3 and C-5 substituted imidazolidines are examples of such products. As such, we have developed a synthesis of 2,4-dione and 2-thioxo-4-one imidazolidinic derivatives by reaction of amino acids with C-phenylglycine, phenyl isocyanate and phenyl isothiocyanate. Four amino-derivatives IG(1-4) and eight imidazolidinic derivatives, IM(1-8), were obtained in yields of 70–74%. The mass, infrared, (1)H and (13)C-NMR spectra of representative products are discussed.

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