Acetamide Derivatives with Antioxidant Activity and Potential Anti-Inflammatory Activity

This study reports the synthesis and antioxidant activity of some new acetamide derivatives. The compounds’ structures were elucidated by NMR analysis and their melting points were measured. The in vitro antioxidant activity of these compounds was tested by evaluating the amount of scavenged ABTS ra...

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Detalles Bibliográficos
Autores principales: Autore, Giuseppina, Caruso, Anna, Marzocco, Stefania, Nicolaus, Barbara, Palladino, Chiara, Pinto, Aldo, Popolo, Ada, Sinicropi, Maria S., Tommonaro, Giuseppina, Saturnino, Carmela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6257181/
https://www.ncbi.nlm.nih.gov/pubmed/20336030
http://dx.doi.org/10.3390/molecules15032028
Descripción
Sumario:This study reports the synthesis and antioxidant activity of some new acetamide derivatives. The compounds’ structures were elucidated by NMR analysis and their melting points were measured. The in vitro antioxidant activity of these compounds was tested by evaluating the amount of scavenged ABTS radical and estimating ROS and NO production in tBOH- or LPS-stimulated J774.A1 macrophages. All compounds were tested for their effect on cell viability by an MTT assay and by a Brine Shrimp Test.

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