Acetamide Derivatives with Antioxidant Activity and Potential Anti-Inflammatory Activity

This study reports the synthesis and antioxidant activity of some new acetamide derivatives. The compounds’ structures were elucidated by NMR analysis and their melting points were measured. The in vitro antioxidant activity of these compounds was tested by evaluating the amount of scavenged ABTS ra...

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Autores principales: Autore, Giuseppina, Caruso, Anna, Marzocco, Stefania, Nicolaus, Barbara, Palladino, Chiara, Pinto, Aldo, Popolo, Ada, Sinicropi, Maria S., Tommonaro, Giuseppina, Saturnino, Carmela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6257181/
https://www.ncbi.nlm.nih.gov/pubmed/20336030
http://dx.doi.org/10.3390/molecules15032028
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author Autore, Giuseppina
Caruso, Anna
Marzocco, Stefania
Nicolaus, Barbara
Palladino, Chiara
Pinto, Aldo
Popolo, Ada
Sinicropi, Maria S.
Tommonaro, Giuseppina
Saturnino, Carmela
author_facet Autore, Giuseppina
Caruso, Anna
Marzocco, Stefania
Nicolaus, Barbara
Palladino, Chiara
Pinto, Aldo
Popolo, Ada
Sinicropi, Maria S.
Tommonaro, Giuseppina
Saturnino, Carmela
author_sort Autore, Giuseppina
collection PubMed
description This study reports the synthesis and antioxidant activity of some new acetamide derivatives. The compounds’ structures were elucidated by NMR analysis and their melting points were measured. The in vitro antioxidant activity of these compounds was tested by evaluating the amount of scavenged ABTS radical and estimating ROS and NO production in tBOH- or LPS-stimulated J774.A1 macrophages. All compounds were tested for their effect on cell viability by an MTT assay and by a Brine Shrimp Test.
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spelling pubmed-62571812018-12-04 Acetamide Derivatives with Antioxidant Activity and Potential Anti-Inflammatory Activity Autore, Giuseppina Caruso, Anna Marzocco, Stefania Nicolaus, Barbara Palladino, Chiara Pinto, Aldo Popolo, Ada Sinicropi, Maria S. Tommonaro, Giuseppina Saturnino, Carmela Molecules Article This study reports the synthesis and antioxidant activity of some new acetamide derivatives. The compounds’ structures were elucidated by NMR analysis and their melting points were measured. The in vitro antioxidant activity of these compounds was tested by evaluating the amount of scavenged ABTS radical and estimating ROS and NO production in tBOH- or LPS-stimulated J774.A1 macrophages. All compounds were tested for their effect on cell viability by an MTT assay and by a Brine Shrimp Test. Molecular Diversity Preservation International 2010-03-23 /pmc/articles/PMC6257181/ /pubmed/20336030 http://dx.doi.org/10.3390/molecules15032028 Text en © 2010 by the authors; http://creativecommons.org/licenses/by/3.0/ licensee Molecular Diversity Preservation International, Basel, Switzerland. This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Autore, Giuseppina
Caruso, Anna
Marzocco, Stefania
Nicolaus, Barbara
Palladino, Chiara
Pinto, Aldo
Popolo, Ada
Sinicropi, Maria S.
Tommonaro, Giuseppina
Saturnino, Carmela
Acetamide Derivatives with Antioxidant Activity and Potential Anti-Inflammatory Activity
title Acetamide Derivatives with Antioxidant Activity and Potential Anti-Inflammatory Activity
title_full Acetamide Derivatives with Antioxidant Activity and Potential Anti-Inflammatory Activity
title_fullStr Acetamide Derivatives with Antioxidant Activity and Potential Anti-Inflammatory Activity
title_full_unstemmed Acetamide Derivatives with Antioxidant Activity and Potential Anti-Inflammatory Activity
title_short Acetamide Derivatives with Antioxidant Activity and Potential Anti-Inflammatory Activity
title_sort acetamide derivatives with antioxidant activity and potential anti-inflammatory activity
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6257181/
https://www.ncbi.nlm.nih.gov/pubmed/20336030
http://dx.doi.org/10.3390/molecules15032028
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