A New Geldanamycin Analogue from Streptomyces hygroscopicus

A new geldanamycin analogue was isolated from Streptomyces hygroscopicus A070101. The structure was elucidated as 11-methoxy-17-formyl-17-demethoxy-18-O-21-O-dihydrogeldanamycin (1) on the basis of extensive 1D and 2D NMR as well as HRESI-MS spectroscopic data analysis. Compound 1 showed considerabl...

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Detalles Bibliográficos
Autores principales: Zhang, Hao, Sun, Guang-Zhi, Li, Xiang, Pan, Hong-Yu, Zhang, Yan-Sheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International 2010
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6257182/
https://www.ncbi.nlm.nih.gov/pubmed/20335971
http://dx.doi.org/10.3390/molecules15031161
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author Zhang, Hao
Sun, Guang-Zhi
Li, Xiang
Pan, Hong-Yu
Zhang, Yan-Sheng
author_facet Zhang, Hao
Sun, Guang-Zhi
Li, Xiang
Pan, Hong-Yu
Zhang, Yan-Sheng
author_sort Zhang, Hao
collection PubMed
description A new geldanamycin analogue was isolated from Streptomyces hygroscopicus A070101. The structure was elucidated as 11-methoxy-17-formyl-17-demethoxy-18-O-21-O-dihydrogeldanamycin (1) on the basis of extensive 1D and 2D NMR as well as HRESI-MS spectroscopic data analysis. Compound 1 showed considerable cytotoxicity (SRB) against human cancer cell lines (breast cancer MCF-7, skin melanoma SK-MEL-2 and lung carcinoma COR-L23).
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spelling pubmed-62571822018-12-04 A New Geldanamycin Analogue from Streptomyces hygroscopicus Zhang, Hao Sun, Guang-Zhi Li, Xiang Pan, Hong-Yu Zhang, Yan-Sheng Molecules Communication A new geldanamycin analogue was isolated from Streptomyces hygroscopicus A070101. The structure was elucidated as 11-methoxy-17-formyl-17-demethoxy-18-O-21-O-dihydrogeldanamycin (1) on the basis of extensive 1D and 2D NMR as well as HRESI-MS spectroscopic data analysis. Compound 1 showed considerable cytotoxicity (SRB) against human cancer cell lines (breast cancer MCF-7, skin melanoma SK-MEL-2 and lung carcinoma COR-L23). Molecular Diversity Preservation International 2010-03-03 /pmc/articles/PMC6257182/ /pubmed/20335971 http://dx.doi.org/10.3390/molecules15031161 Text en © 2010 by the authors; http://creativecommons.org/licenses/by/3.0/ licensee Molecular Diversity Preservation International, Basel, Switzerland. This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Communication
Zhang, Hao
Sun, Guang-Zhi
Li, Xiang
Pan, Hong-Yu
Zhang, Yan-Sheng
A New Geldanamycin Analogue from Streptomyces hygroscopicus
title A New Geldanamycin Analogue from Streptomyces hygroscopicus
title_full A New Geldanamycin Analogue from Streptomyces hygroscopicus
title_fullStr A New Geldanamycin Analogue from Streptomyces hygroscopicus
title_full_unstemmed A New Geldanamycin Analogue from Streptomyces hygroscopicus
title_short A New Geldanamycin Analogue from Streptomyces hygroscopicus
title_sort new geldanamycin analogue from streptomyces hygroscopicus
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6257182/
https://www.ncbi.nlm.nih.gov/pubmed/20335971
http://dx.doi.org/10.3390/molecules15031161
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