Synthesis and Antimicrobial Activity of New 4-Heteroarylamino Coumarin Derivatives Containing Nitrogen and Sulfur as Heteroatoms

ynthesis, spectral analysis and bioactivity of new coumarin derivatives are described in this paper. Eight new coumarin derivatives were synthesized in moderate to good yields by condensation of 4-chloro-3-nitrocoumarin and the corresponding heteroarylamine. The synthesized compounds were tested for...

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Autores principales: Dekić, Biljana R., Radulović, Niko S., Dekić, Vidoslav S., Vukićević, Rastko D., Palić, Radosav M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6257190/
https://www.ncbi.nlm.nih.gov/pubmed/20428040
http://dx.doi.org/10.3390/molecules15042246
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author Dekić, Biljana R.
Radulović, Niko S.
Dekić, Vidoslav S.
Vukićević, Rastko D.
Palić, Radosav M.
author_facet Dekić, Biljana R.
Radulović, Niko S.
Dekić, Vidoslav S.
Vukićević, Rastko D.
Palić, Radosav M.
author_sort Dekić, Biljana R.
collection PubMed
description ynthesis, spectral analysis and bioactivity of new coumarin derivatives are described in this paper. Eight new coumarin derivatives were synthesized in moderate to good yields by condensation of 4-chloro-3-nitrocoumarin and the corresponding heteroarylamine. The synthesized compounds were tested for their in vitro antimicrobial activity, in a standard disk diffusion assay, against thirteen strains of bacteria and three fungal strains. They have shown a wide range of activity - from one completely inactive compound to medium active ones.
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spelling pubmed-62571902018-11-30 Synthesis and Antimicrobial Activity of New 4-Heteroarylamino Coumarin Derivatives Containing Nitrogen and Sulfur as Heteroatoms Dekić, Biljana R. Radulović, Niko S. Dekić, Vidoslav S. Vukićević, Rastko D. Palić, Radosav M. Molecules Article ynthesis, spectral analysis and bioactivity of new coumarin derivatives are described in this paper. Eight new coumarin derivatives were synthesized in moderate to good yields by condensation of 4-chloro-3-nitrocoumarin and the corresponding heteroarylamine. The synthesized compounds were tested for their in vitro antimicrobial activity, in a standard disk diffusion assay, against thirteen strains of bacteria and three fungal strains. They have shown a wide range of activity - from one completely inactive compound to medium active ones. Molecular Diversity Preservation International 2010-03-30 /pmc/articles/PMC6257190/ /pubmed/20428040 http://dx.doi.org/10.3390/molecules15042246 Text en © 2010 by the authors; http://creativecommons.org/licenses/by/3.0/ licensee Molecular Diversity Preservation International, Basel, Switzerland. This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Dekić, Biljana R.
Radulović, Niko S.
Dekić, Vidoslav S.
Vukićević, Rastko D.
Palić, Radosav M.
Synthesis and Antimicrobial Activity of New 4-Heteroarylamino Coumarin Derivatives Containing Nitrogen and Sulfur as Heteroatoms
title Synthesis and Antimicrobial Activity of New 4-Heteroarylamino Coumarin Derivatives Containing Nitrogen and Sulfur as Heteroatoms
title_full Synthesis and Antimicrobial Activity of New 4-Heteroarylamino Coumarin Derivatives Containing Nitrogen and Sulfur as Heteroatoms
title_fullStr Synthesis and Antimicrobial Activity of New 4-Heteroarylamino Coumarin Derivatives Containing Nitrogen and Sulfur as Heteroatoms
title_full_unstemmed Synthesis and Antimicrobial Activity of New 4-Heteroarylamino Coumarin Derivatives Containing Nitrogen and Sulfur as Heteroatoms
title_short Synthesis and Antimicrobial Activity of New 4-Heteroarylamino Coumarin Derivatives Containing Nitrogen and Sulfur as Heteroatoms
title_sort synthesis and antimicrobial activity of new 4-heteroarylamino coumarin derivatives containing nitrogen and sulfur as heteroatoms
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6257190/
https://www.ncbi.nlm.nih.gov/pubmed/20428040
http://dx.doi.org/10.3390/molecules15042246
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