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Synthesis and Antimicrobial Activities of Some New 1,2,4-Triazole Derivatives

Some novel 4,5-disubstituted-2,4-dihydro-3H-1,2,4-triazol-3-one (3, 6, 8, 9) derivatives and or 3-(4-methylphenyl)[1,2,4]triazolo[3,4-b][1,3]benzoxazole (5) were synthesized from the reaction of various ester ethoxycarbonylhydrazones (1a-e) with several primary amines. The synthesis of 4-amino-5-(4-...

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Autores principales: Bektaş, Hakan, Karaali, Nesrin, Şahin, Deniz, Demirbaş, Ahmet, Karaoglu, Şengül Alpay, Demirbaş, Neslihan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6257194/
https://www.ncbi.nlm.nih.gov/pubmed/20428053
http://dx.doi.org/10.3390/molecules15042427
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author Bektaş, Hakan
Karaali, Nesrin
Şahin, Deniz
Demirbaş, Ahmet
Karaoglu, Şengül Alpay
Demirbaş, Neslihan
author_facet Bektaş, Hakan
Karaali, Nesrin
Şahin, Deniz
Demirbaş, Ahmet
Karaoglu, Şengül Alpay
Demirbaş, Neslihan
author_sort Bektaş, Hakan
collection PubMed
description Some novel 4,5-disubstituted-2,4-dihydro-3H-1,2,4-triazol-3-one (3, 6, 8, 9) derivatives and or 3-(4-methylphenyl)[1,2,4]triazolo[3,4-b][1,3]benzoxazole (5) were synthesized from the reaction of various ester ethoxycarbonylhydrazones (1a-e) with several primary amines. The synthesis of 4-amino-5-(4-chlorophenyl)-2-[(5-mercapto-1,3,4-oxadiazol-2-yl)methyl]-2,4-dihydro-3H-1,2,4-triazol-3-one (13) was performed starting from 4-Amino-5-(4-chlorophenyl)-2,4-dihydro-3H-1,2,4-triazol-3-one (2) by four steps; then 13 was converted to the corresponding Schiff base (14) by using 4-methoxybenzaldehyde. Finally, two Mannich base derivatives of 14 were obtained by using morpholine or methyl piperazine as amine component. All newly synthesized compounds were screened for their antimicrobial activities and some of which were found to possess good or moderate activities against the test microorganisms.
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spelling pubmed-62571942018-11-30 Synthesis and Antimicrobial Activities of Some New 1,2,4-Triazole Derivatives Bektaş, Hakan Karaali, Nesrin Şahin, Deniz Demirbaş, Ahmet Karaoglu, Şengül Alpay Demirbaş, Neslihan Molecules Article Some novel 4,5-disubstituted-2,4-dihydro-3H-1,2,4-triazol-3-one (3, 6, 8, 9) derivatives and or 3-(4-methylphenyl)[1,2,4]triazolo[3,4-b][1,3]benzoxazole (5) were synthesized from the reaction of various ester ethoxycarbonylhydrazones (1a-e) with several primary amines. The synthesis of 4-amino-5-(4-chlorophenyl)-2-[(5-mercapto-1,3,4-oxadiazol-2-yl)methyl]-2,4-dihydro-3H-1,2,4-triazol-3-one (13) was performed starting from 4-Amino-5-(4-chlorophenyl)-2,4-dihydro-3H-1,2,4-triazol-3-one (2) by four steps; then 13 was converted to the corresponding Schiff base (14) by using 4-methoxybenzaldehyde. Finally, two Mannich base derivatives of 14 were obtained by using morpholine or methyl piperazine as amine component. All newly synthesized compounds were screened for their antimicrobial activities and some of which were found to possess good or moderate activities against the test microorganisms. Molecular Diversity Preservation International 2010-04-08 /pmc/articles/PMC6257194/ /pubmed/20428053 http://dx.doi.org/10.3390/molecules15042427 Text en © 2010 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland. This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Bektaş, Hakan
Karaali, Nesrin
Şahin, Deniz
Demirbaş, Ahmet
Karaoglu, Şengül Alpay
Demirbaş, Neslihan
Synthesis and Antimicrobial Activities of Some New 1,2,4-Triazole Derivatives
title Synthesis and Antimicrobial Activities of Some New 1,2,4-Triazole Derivatives
title_full Synthesis and Antimicrobial Activities of Some New 1,2,4-Triazole Derivatives
title_fullStr Synthesis and Antimicrobial Activities of Some New 1,2,4-Triazole Derivatives
title_full_unstemmed Synthesis and Antimicrobial Activities of Some New 1,2,4-Triazole Derivatives
title_short Synthesis and Antimicrobial Activities of Some New 1,2,4-Triazole Derivatives
title_sort synthesis and antimicrobial activities of some new 1,2,4-triazole derivatives
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6257194/
https://www.ncbi.nlm.nih.gov/pubmed/20428053
http://dx.doi.org/10.3390/molecules15042427
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