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Synthesis and Antimicrobial Activities of Some New 1,2,4-Triazole Derivatives
Some novel 4,5-disubstituted-2,4-dihydro-3H-1,2,4-triazol-3-one (3, 6, 8, 9) derivatives and or 3-(4-methylphenyl)[1,2,4]triazolo[3,4-b][1,3]benzoxazole (5) were synthesized from the reaction of various ester ethoxycarbonylhydrazones (1a-e) with several primary amines. The synthesis of 4-amino-5-(4-...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Molecular Diversity Preservation International
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6257194/ https://www.ncbi.nlm.nih.gov/pubmed/20428053 http://dx.doi.org/10.3390/molecules15042427 |
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author | Bektaş, Hakan Karaali, Nesrin Şahin, Deniz Demirbaş, Ahmet Karaoglu, Şengül Alpay Demirbaş, Neslihan |
author_facet | Bektaş, Hakan Karaali, Nesrin Şahin, Deniz Demirbaş, Ahmet Karaoglu, Şengül Alpay Demirbaş, Neslihan |
author_sort | Bektaş, Hakan |
collection | PubMed |
description | Some novel 4,5-disubstituted-2,4-dihydro-3H-1,2,4-triazol-3-one (3, 6, 8, 9) derivatives and or 3-(4-methylphenyl)[1,2,4]triazolo[3,4-b][1,3]benzoxazole (5) were synthesized from the reaction of various ester ethoxycarbonylhydrazones (1a-e) with several primary amines. The synthesis of 4-amino-5-(4-chlorophenyl)-2-[(5-mercapto-1,3,4-oxadiazol-2-yl)methyl]-2,4-dihydro-3H-1,2,4-triazol-3-one (13) was performed starting from 4-Amino-5-(4-chlorophenyl)-2,4-dihydro-3H-1,2,4-triazol-3-one (2) by four steps; then 13 was converted to the corresponding Schiff base (14) by using 4-methoxybenzaldehyde. Finally, two Mannich base derivatives of 14 were obtained by using morpholine or methyl piperazine as amine component. All newly synthesized compounds were screened for their antimicrobial activities and some of which were found to possess good or moderate activities against the test microorganisms. |
format | Online Article Text |
id | pubmed-6257194 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | Molecular Diversity Preservation International |
record_format | MEDLINE/PubMed |
spelling | pubmed-62571942018-11-30 Synthesis and Antimicrobial Activities of Some New 1,2,4-Triazole Derivatives Bektaş, Hakan Karaali, Nesrin Şahin, Deniz Demirbaş, Ahmet Karaoglu, Şengül Alpay Demirbaş, Neslihan Molecules Article Some novel 4,5-disubstituted-2,4-dihydro-3H-1,2,4-triazol-3-one (3, 6, 8, 9) derivatives and or 3-(4-methylphenyl)[1,2,4]triazolo[3,4-b][1,3]benzoxazole (5) were synthesized from the reaction of various ester ethoxycarbonylhydrazones (1a-e) with several primary amines. The synthesis of 4-amino-5-(4-chlorophenyl)-2-[(5-mercapto-1,3,4-oxadiazol-2-yl)methyl]-2,4-dihydro-3H-1,2,4-triazol-3-one (13) was performed starting from 4-Amino-5-(4-chlorophenyl)-2,4-dihydro-3H-1,2,4-triazol-3-one (2) by four steps; then 13 was converted to the corresponding Schiff base (14) by using 4-methoxybenzaldehyde. Finally, two Mannich base derivatives of 14 were obtained by using morpholine or methyl piperazine as amine component. All newly synthesized compounds were screened for their antimicrobial activities and some of which were found to possess good or moderate activities against the test microorganisms. Molecular Diversity Preservation International 2010-04-08 /pmc/articles/PMC6257194/ /pubmed/20428053 http://dx.doi.org/10.3390/molecules15042427 Text en © 2010 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland. This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Article Bektaş, Hakan Karaali, Nesrin Şahin, Deniz Demirbaş, Ahmet Karaoglu, Şengül Alpay Demirbaş, Neslihan Synthesis and Antimicrobial Activities of Some New 1,2,4-Triazole Derivatives |
title | Synthesis and Antimicrobial Activities of Some New 1,2,4-Triazole Derivatives |
title_full | Synthesis and Antimicrobial Activities of Some New 1,2,4-Triazole Derivatives |
title_fullStr | Synthesis and Antimicrobial Activities of Some New 1,2,4-Triazole Derivatives |
title_full_unstemmed | Synthesis and Antimicrobial Activities of Some New 1,2,4-Triazole Derivatives |
title_short | Synthesis and Antimicrobial Activities of Some New 1,2,4-Triazole Derivatives |
title_sort | synthesis and antimicrobial activities of some new 1,2,4-triazole derivatives |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6257194/ https://www.ncbi.nlm.nih.gov/pubmed/20428053 http://dx.doi.org/10.3390/molecules15042427 |
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