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Chemical Constituents of Excoecaria acerifolia and Their Bioactivities
A new kaurane diterpenoid, 3α,18-dihydroxy-3β,20-epoxykaur-15-ene (1), was isolated from the aerial parts of Excoecaria acerifolia (Euphorbiaceae) together with 16 known compounds. Their structures were identified by extensive spectral analysis, especially 2D NMR techniques. Antiangiogenic effects o...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Molecular Diversity Preservation International
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6257216/ https://www.ncbi.nlm.nih.gov/pubmed/20428036 http://dx.doi.org/10.3390/molecules15042178 |
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author | Zhao, Yan-Li He, Qiu-Xia Li, Yang Wang, Si-Feng Liu, Ke-Chun Yang, Yong-Ping Li, Xiao-Li |
author_facet | Zhao, Yan-Li He, Qiu-Xia Li, Yang Wang, Si-Feng Liu, Ke-Chun Yang, Yong-Ping Li, Xiao-Li |
author_sort | Zhao, Yan-Li |
collection | PubMed |
description | A new kaurane diterpenoid, 3α,18-dihydroxy-3β,20-epoxykaur-15-ene (1), was isolated from the aerial parts of Excoecaria acerifolia (Euphorbiaceae) together with 16 known compounds. Their structures were identified by extensive spectral analysis, especially 2D NMR techniques. Antiangiogenic effects of compounds 1-6 and 9-17 were evaluated using a zebrafish model, with compound 9 being active in this bioassay. At the same time, compounds 4, 6, 10, 11 showed activity in inhibiting the growth of A549 lung cancer cells, and the compound 10 also showed apoptosis-inducing effects on A549 lung cancer cells. |
format | Online Article Text |
id | pubmed-6257216 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | Molecular Diversity Preservation International |
record_format | MEDLINE/PubMed |
spelling | pubmed-62572162018-11-30 Chemical Constituents of Excoecaria acerifolia and Their Bioactivities Zhao, Yan-Li He, Qiu-Xia Li, Yang Wang, Si-Feng Liu, Ke-Chun Yang, Yong-Ping Li, Xiao-Li Molecules Communication A new kaurane diterpenoid, 3α,18-dihydroxy-3β,20-epoxykaur-15-ene (1), was isolated from the aerial parts of Excoecaria acerifolia (Euphorbiaceae) together with 16 known compounds. Their structures were identified by extensive spectral analysis, especially 2D NMR techniques. Antiangiogenic effects of compounds 1-6 and 9-17 were evaluated using a zebrafish model, with compound 9 being active in this bioassay. At the same time, compounds 4, 6, 10, 11 showed activity in inhibiting the growth of A549 lung cancer cells, and the compound 10 also showed apoptosis-inducing effects on A549 lung cancer cells. Molecular Diversity Preservation International 2010-03-26 /pmc/articles/PMC6257216/ /pubmed/20428036 http://dx.doi.org/10.3390/molecules15042178 Text en © 2010 by the authors; http://creativecommons.org/licenses/by/3.0/ licensee Molecular Diversity Preservation International, Basel, Switzerland. This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Communication Zhao, Yan-Li He, Qiu-Xia Li, Yang Wang, Si-Feng Liu, Ke-Chun Yang, Yong-Ping Li, Xiao-Li Chemical Constituents of Excoecaria acerifolia and Their Bioactivities |
title | Chemical Constituents of Excoecaria acerifolia and Their Bioactivities |
title_full | Chemical Constituents of Excoecaria acerifolia and Their Bioactivities |
title_fullStr | Chemical Constituents of Excoecaria acerifolia and Their Bioactivities |
title_full_unstemmed | Chemical Constituents of Excoecaria acerifolia and Their Bioactivities |
title_short | Chemical Constituents of Excoecaria acerifolia and Their Bioactivities |
title_sort | chemical constituents of excoecaria acerifolia and their bioactivities |
topic | Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6257216/ https://www.ncbi.nlm.nih.gov/pubmed/20428036 http://dx.doi.org/10.3390/molecules15042178 |
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