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Chemical Constituents of Excoecaria acerifolia and Their Bioactivities

A new kaurane diterpenoid, 3α,18-dihydroxy-3β,20-epoxykaur-15-ene (1), was isolated from the aerial parts of Excoecaria acerifolia (Euphorbiaceae) together with 16 known compounds. Their structures were identified by extensive spectral analysis, especially 2D NMR techniques. Antiangiogenic effects o...

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Autores principales: Zhao, Yan-Li, He, Qiu-Xia, Li, Yang, Wang, Si-Feng, Liu, Ke-Chun, Yang, Yong-Ping, Li, Xiao-Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6257216/
https://www.ncbi.nlm.nih.gov/pubmed/20428036
http://dx.doi.org/10.3390/molecules15042178
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author Zhao, Yan-Li
He, Qiu-Xia
Li, Yang
Wang, Si-Feng
Liu, Ke-Chun
Yang, Yong-Ping
Li, Xiao-Li
author_facet Zhao, Yan-Li
He, Qiu-Xia
Li, Yang
Wang, Si-Feng
Liu, Ke-Chun
Yang, Yong-Ping
Li, Xiao-Li
author_sort Zhao, Yan-Li
collection PubMed
description A new kaurane diterpenoid, 3α,18-dihydroxy-3β,20-epoxykaur-15-ene (1), was isolated from the aerial parts of Excoecaria acerifolia (Euphorbiaceae) together with 16 known compounds. Their structures were identified by extensive spectral analysis, especially 2D NMR techniques. Antiangiogenic effects of compounds 1-6 and 9-17 were evaluated using a zebrafish model, with compound 9 being active in this bioassay. At the same time, compounds 4, 6, 10, 11 showed activity in inhibiting the growth of A549 lung cancer cells, and the compound 10 also showed apoptosis-inducing effects on A549 lung cancer cells.
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spelling pubmed-62572162018-11-30 Chemical Constituents of Excoecaria acerifolia and Their Bioactivities Zhao, Yan-Li He, Qiu-Xia Li, Yang Wang, Si-Feng Liu, Ke-Chun Yang, Yong-Ping Li, Xiao-Li Molecules Communication A new kaurane diterpenoid, 3α,18-dihydroxy-3β,20-epoxykaur-15-ene (1), was isolated from the aerial parts of Excoecaria acerifolia (Euphorbiaceae) together with 16 known compounds. Their structures were identified by extensive spectral analysis, especially 2D NMR techniques. Antiangiogenic effects of compounds 1-6 and 9-17 were evaluated using a zebrafish model, with compound 9 being active in this bioassay. At the same time, compounds 4, 6, 10, 11 showed activity in inhibiting the growth of A549 lung cancer cells, and the compound 10 also showed apoptosis-inducing effects on A549 lung cancer cells. Molecular Diversity Preservation International 2010-03-26 /pmc/articles/PMC6257216/ /pubmed/20428036 http://dx.doi.org/10.3390/molecules15042178 Text en © 2010 by the authors; http://creativecommons.org/licenses/by/3.0/ licensee Molecular Diversity Preservation International, Basel, Switzerland. This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Communication
Zhao, Yan-Li
He, Qiu-Xia
Li, Yang
Wang, Si-Feng
Liu, Ke-Chun
Yang, Yong-Ping
Li, Xiao-Li
Chemical Constituents of Excoecaria acerifolia and Their Bioactivities
title Chemical Constituents of Excoecaria acerifolia and Their Bioactivities
title_full Chemical Constituents of Excoecaria acerifolia and Their Bioactivities
title_fullStr Chemical Constituents of Excoecaria acerifolia and Their Bioactivities
title_full_unstemmed Chemical Constituents of Excoecaria acerifolia and Their Bioactivities
title_short Chemical Constituents of Excoecaria acerifolia and Their Bioactivities
title_sort chemical constituents of excoecaria acerifolia and their bioactivities
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6257216/
https://www.ncbi.nlm.nih.gov/pubmed/20428036
http://dx.doi.org/10.3390/molecules15042178
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