Molecular Recognition Studies on Naphthyridine Derivatives

The association constants K(b) of three hosts I–III designed to have both enhanced hydrogen bonding donor strength and conformational preorganization with biotin analogues 1–5 are reported. (1)H-NMR titrations under two different concentration conditions have been employed to determine the associati...

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Detalles Bibliográficos
Autores principales: Iglesias-Sánchez, José Carlos, María, Dolores Santa, Claramunt, Rosa M., Elguero, José
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6257231/
https://www.ncbi.nlm.nih.gov/pubmed/20335974
http://dx.doi.org/10.3390/molecules15031213
Descripción
Sumario:The association constants K(b) of three hosts I–III designed to have both enhanced hydrogen bonding donor strength and conformational preorganization with biotin analogues 1–5 are reported. (1)H-NMR titrations under two different concentration conditions have been employed to determine the association constants K(b). A statistical analysis using a presence absence matrix has been applied to calculate the different contributions. Hydrogen bond interactions make naphthyridine derivatives II and III potent binders and effective receptors for (+)-biotin methyl ester (1), due to the complex stabilization by additional hydrogen bonds.

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