Elucidating Drug-Enzyme Interactions and Their Structural Basis for Improving the Affinity and Potency of Isoniazid and Its Derivatives Based on Computer Modeling Approaches

The enoyl-ACP reductase enzyme (InhA) from M. tuberculosis is recognized as the primary target of isoniazid (INH), a first-line antibiotic for tuberculosis treatment. To identify the specific interactions of INH-NAD adduct and its derivative adducts in InhA binding pocket, molecular docking calculat...

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Detalles Bibliográficos
Autores principales: Punkvang, Auradee, Saparpakorn, Patchreenart, Hannongbua, Supa, Wolschann, Peter, Pungpo, Pornpan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6257264/
https://www.ncbi.nlm.nih.gov/pubmed/20428080
http://dx.doi.org/10.3390/molecules15042791

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6257264/
https://www.ncbi.nlm.nih.gov/pubmed/20428080
http://dx.doi.org/10.3390/molecules15042791

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