Conjugate Addition of Nucleophiles to the Vinyl Function of 2-Chloro-4-vinylpyrimidine Derivatives

Conjugate addition reaction of various nucleophiles across the vinyl group of 2-chloro-4-vinylpyrimidine, 2-chloro-4-(1-phenylvinyl)pyrimidine and 2-chloro-4-vinyl-quinazoline provides the corresponding 2-chloro-4-(2-substituted ethyl)pyrimidines and 2-chloro-4-(2-substituted ethyl)quinazolines. Tre...

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Autores principales: Raux, Elizabeth, Klenc, Jeffrey, Blake, Ava, Sączewski, Jarosław, Strekowski, Lucjan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6257268/
https://www.ncbi.nlm.nih.gov/pubmed/20336026
http://dx.doi.org/10.3390/molecules15031973
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author Raux, Elizabeth
Klenc, Jeffrey
Blake, Ava
Sączewski, Jarosław
Strekowski, Lucjan
author_facet Raux, Elizabeth
Klenc, Jeffrey
Blake, Ava
Sączewski, Jarosław
Strekowski, Lucjan
author_sort Raux, Elizabeth
collection PubMed
description Conjugate addition reaction of various nucleophiles across the vinyl group of 2-chloro-4-vinylpyrimidine, 2-chloro-4-(1-phenylvinyl)pyrimidine and 2-chloro-4-vinyl-quinazoline provides the corresponding 2-chloro-4-(2-substituted ethyl)pyrimidines and 2-chloro-4-(2-substituted ethyl)quinazolines. Treatment of these products, without isolation, with N-methylpiperazine results in nucleophilic displacement of chloride and yields the corresponding 2,4-disubstituted pyrimidines and quinazolines.
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spelling pubmed-62572682018-12-04 Conjugate Addition of Nucleophiles to the Vinyl Function of 2-Chloro-4-vinylpyrimidine Derivatives Raux, Elizabeth Klenc, Jeffrey Blake, Ava Sączewski, Jarosław Strekowski, Lucjan Molecules Article Conjugate addition reaction of various nucleophiles across the vinyl group of 2-chloro-4-vinylpyrimidine, 2-chloro-4-(1-phenylvinyl)pyrimidine and 2-chloro-4-vinyl-quinazoline provides the corresponding 2-chloro-4-(2-substituted ethyl)pyrimidines and 2-chloro-4-(2-substituted ethyl)quinazolines. Treatment of these products, without isolation, with N-methylpiperazine results in nucleophilic displacement of chloride and yields the corresponding 2,4-disubstituted pyrimidines and quinazolines. Molecular Diversity Preservation International 2010-03-19 /pmc/articles/PMC6257268/ /pubmed/20336026 http://dx.doi.org/10.3390/molecules15031973 Text en © 2010 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland. This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Raux, Elizabeth
Klenc, Jeffrey
Blake, Ava
Sączewski, Jarosław
Strekowski, Lucjan
Conjugate Addition of Nucleophiles to the Vinyl Function of 2-Chloro-4-vinylpyrimidine Derivatives
title Conjugate Addition of Nucleophiles to the Vinyl Function of 2-Chloro-4-vinylpyrimidine Derivatives
title_full Conjugate Addition of Nucleophiles to the Vinyl Function of 2-Chloro-4-vinylpyrimidine Derivatives
title_fullStr Conjugate Addition of Nucleophiles to the Vinyl Function of 2-Chloro-4-vinylpyrimidine Derivatives
title_full_unstemmed Conjugate Addition of Nucleophiles to the Vinyl Function of 2-Chloro-4-vinylpyrimidine Derivatives
title_short Conjugate Addition of Nucleophiles to the Vinyl Function of 2-Chloro-4-vinylpyrimidine Derivatives
title_sort conjugate addition of nucleophiles to the vinyl function of 2-chloro-4-vinylpyrimidine derivatives
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6257268/
https://www.ncbi.nlm.nih.gov/pubmed/20336026
http://dx.doi.org/10.3390/molecules15031973
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AT saczewskijarosław conjugateadditionofnucleophilestothevinylfunctionof2chloro4vinylpyrimidinederivatives
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