Catalytic Asymmetric Nitro-Mannich Reactions with a Yb/K Heterobimetallic Catalyst

A catalytic asymmetric nitro-Mannich (aza-Henry) reaction with rare earth metal/alkali metal heterobimetallic catalysts is described. A Yb/K heterobimetallic catalyst assembled by an amide-based ligand promoted the asymmetric nitro-Mannich reaction to afford enantioenriched anti-β-nitroamines in up...

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Detalles Bibliográficos
Autores principales: Nitabaru, Tatsuya, Kumagai, Naoya, Shibasaki, Masakatsu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6257270/
https://www.ncbi.nlm.nih.gov/pubmed/20335980
http://dx.doi.org/10.3390/molecules15031280
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author Nitabaru, Tatsuya
Kumagai, Naoya
Shibasaki, Masakatsu
author_facet Nitabaru, Tatsuya
Kumagai, Naoya
Shibasaki, Masakatsu
author_sort Nitabaru, Tatsuya
collection PubMed
description A catalytic asymmetric nitro-Mannich (aza-Henry) reaction with rare earth metal/alkali metal heterobimetallic catalysts is described. A Yb/K heterobimetallic catalyst assembled by an amide-based ligand promoted the asymmetric nitro-Mannich reaction to afford enantioenriched anti-β-nitroamines in up to 86% ee. Facile reduction of the nitro functionality allowed for efficient access to optically active 1,2-diamines.
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spelling pubmed-62572702018-12-04 Catalytic Asymmetric Nitro-Mannich Reactions with a Yb/K Heterobimetallic Catalyst Nitabaru, Tatsuya Kumagai, Naoya Shibasaki, Masakatsu Molecules Article A catalytic asymmetric nitro-Mannich (aza-Henry) reaction with rare earth metal/alkali metal heterobimetallic catalysts is described. A Yb/K heterobimetallic catalyst assembled by an amide-based ligand promoted the asymmetric nitro-Mannich reaction to afford enantioenriched anti-β-nitroamines in up to 86% ee. Facile reduction of the nitro functionality allowed for efficient access to optically active 1,2-diamines. Molecular Diversity Preservation International 2010-03-04 /pmc/articles/PMC6257270/ /pubmed/20335980 http://dx.doi.org/10.3390/molecules15031280 Text en © 2010 by the authors; http://creativecommons.org/licenses/by/3.0/ licensee Molecular Diversity Preservation International, Basel, Switzerland. This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Nitabaru, Tatsuya
Kumagai, Naoya
Shibasaki, Masakatsu
Catalytic Asymmetric Nitro-Mannich Reactions with a Yb/K Heterobimetallic Catalyst
title Catalytic Asymmetric Nitro-Mannich Reactions with a Yb/K Heterobimetallic Catalyst
title_full Catalytic Asymmetric Nitro-Mannich Reactions with a Yb/K Heterobimetallic Catalyst
title_fullStr Catalytic Asymmetric Nitro-Mannich Reactions with a Yb/K Heterobimetallic Catalyst
title_full_unstemmed Catalytic Asymmetric Nitro-Mannich Reactions with a Yb/K Heterobimetallic Catalyst
title_short Catalytic Asymmetric Nitro-Mannich Reactions with a Yb/K Heterobimetallic Catalyst
title_sort catalytic asymmetric nitro-mannich reactions with a yb/k heterobimetallic catalyst
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6257270/
https://www.ncbi.nlm.nih.gov/pubmed/20335980
http://dx.doi.org/10.3390/molecules15031280
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